Recent pharmacogenomic/pharmacogenetic (PGx) studies have disclosed important roles
for drug transporters in the human body. Changes in the functions of drug transporters due …

Phase I and II drug metabolizing enzymes (DME) and drug transporters are involved in the
absorption, distribution, metabolism as well as elimination of many therapeutic agents …

The membrane transporter P-glycoprotein, encoded by the ABCB1 gene, influences the
pharmacokinetics of anti-cancer drugs. We hypothesized that variants of ABCB1 affect …

Multidrug resistance (MDR), which is mediated by multiple drug efflux ATP-binding cassette
(ABC) transporters, is a critical issue in the treatment of acute leukemia, with permeability …

Acute myeloid leukemia (AML) is one of the most common hematological neoplasia causing
death worldwide. The long-term overall survival is unsatisfactory due to many factors …

Acute lymphoblastic leukemia (ALL) is the major pediatric cancer in developed countries.
Although treatment outcome has improved owing to advances in chemotherapy, there is still …

Abstract Multidrug resistance 1 (MDR1) gene encodes the ATP-dependent cellular efflux
pump P-glycoprotein (P-gp) which efflux of a variety of substances across the membrane. P …

Transporters are divided into the ABC and SLC super-families, mediating the cellular efflux
and influx of various xenobiotic and endogenous substrates. Here, an extensive literature …

The modulation of P-glycoprotein (P-gp, ABCB1) can reverse multidrug resistance (MDR)
and potentiate the efficacy of anticancer drugs. Tea polyphenols, such as epigallocatechin …

Results: The BCRP G34A SNP was the only SNP significantly associated with ALL. Risk
factors included pre-treatment WBC counts and post-treatment peripheral and bone marrow …