Abstract Intracellular calcium (Ca 2+) is a critical coordinator of various aspects of cellular
physiology. It is increasingly apparent that changes in cellular Ca 2+ dynamics contribute to …

Abstract Calcium (Ca 2+) is a highly versatile second messenger that controls vascular
smooth muscle cell (VSMC) contraction, proliferation, and migration. By means of Ca 2+ …

After a period of relative senescence in the field of vascular smooth muscle cell (VSMC)
research with particular regards to atherosclerosis, the last few years has witnessed a …

The cardiac isoform of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA2a) plays a
major role in controlling excitation/contraction coupling. In both experimental and clinical …

Cardiovascular diseases are a major cause of human death worldwide. Excessive
proliferation of vascular smooth muscle cells contributes to the etiology of such diseases …

BACKGROUND: Heart failure (HF) remains a major cause of morbidity and mortality in North
America. With an aging population and an unmet clinical need by current pharmacologic …

Phenotypic modulation of vascular myocytes is important for vascular development and
adaptation. A characteristic feature of this process is alteration in intracellular Ca2+ …

Both increases in the basal cytosolic calcium concentration ([Ca2+] cyt) and [Ca2+] cyt
transients play major roles in cell cycle progression, cell proliferation and division. Calcium …

Background—Pulmonary arterial hypertension (PAH) is characterized by dysregulated
proliferation of pulmonary artery smooth muscle cells leading to (mal) adaptive vascular …

Heart failure (HF) is a major health problem in Western countries. Despite significant
progress in pharmacological and device-based treatment, the disease burden imposed …