Caffeine and purine derivatives represent interesting chemical moieties, which show various
biological activities. Caffeine is an alkaloid that belongs to the family of methylxanthine …

In this study, we investigated the conjugation of theophylline with different compounds of
natural origin hoping to construct new hybrids with dual activity against cholinergic and …

Neurodegenerative diseases (NDs) represent a hallmark of numerous incapacitating and
untreatable conditions, the incidence of which is escalating swiftly, exemplified by …

The synthesis of eleven new and previously undescribed benzamides was designed. These
compounds were specifically projected as potential inhibitors of the enzymes …

Caffeine is one of the privileged natural products that shows numerous effects on the central
nervous system. Herein, thirty-one caffeine-based amide derivatives were synthesized and …

The chromone alkaloid is one of the classical pharmacophores for cyclin-dependent kinases
(CDKs) and represents the first CDK inhibitor to reach clinical trials. Rohitukine (1), a …

Coumarin is a naturally occurring bioactive pharmacophore with wide occurrence among
central nervous system (CNS)-active small molecules. 8-Acetylcoumarin, one of the natural …

The structure‐based virtual screening (SBVS) has gained immense importance in early drug
discovery. Herein, we report the SBVS‐driven identification of new cholinesterase inhibitors …

Berberrubine is a naturally occurring isoquinoline alkaloid and a bioactive metabolite of
berberine. Berberine exhibits a wide range of pharmacological activities, including …

Cholinergic deficit is a characteristic factor of several pathologies, such as myasthenia
gravis, some types of congenital myasthenic syndromes, and Alzheimer's Disease. Two …