The evolving classification of diffuse gliomas: World Health Organization updates for 2021
A Perez, JT Huse - Current neurology and neuroscience reports, 2021 - Springer
Abstract Purpose of Review The upcoming 2021 World Health Organization (WHO)
Classification of Tumours of the Central Nervous System will feature numerous changes in …
Classification of Tumours of the Central Nervous System will feature numerous changes in …
Treatment of pediatric low-grade gliomas
SF Sait, AM Giantini-Larsen, KR Tringale… - Current neurology and …, 2023 - Springer
Abstract Purpose of Review Pediatric low-grade gliomas and glioneuronal tumors (pLGG)
account for approximately 30% of pediatric CNS neoplasms, encompassing a …
account for approximately 30% of pediatric CNS neoplasms, encompassing a …
[HTML][HTML] Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology
D Sturm, D Capper, F Andreiuolo, M Gessi… - Nature medicine, 2023 - nature.com
The large diversity of central nervous system (CNS) tumor types in children and adolescents
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …
[HTML][HTML] Molecular and clinicopathologic features of gliomas harboring NTRK fusions
M Torre, V Vasudevaraja, J Serrano… - Acta Neuropathologica …, 2020 - Springer
Fusions involving neurotrophic tyrosine receptor kinase (NTRK) genes are detected in≤ 2%
of gliomas and can promote gliomagenesis. The remarkable therapeutic efficacy of TRK …
of gliomas and can promote gliomagenesis. The remarkable therapeutic efficacy of TRK …
Molecular biomarker testing for the diagnosis of diffuse gliomas: guideline from the College of American Pathologists in collaboration with the American Association of …
Context.—The diagnosis and clinical management of patients with diffuse gliomas (DGs)
have evolved rapidly over the past decade with the emergence of molecular biomarkers that …
have evolved rapidly over the past decade with the emergence of molecular biomarkers that …
[HTML][HTML] PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum
KT Alhalabi, D Stichel, P Sievers, H Peterziel… - Acta …, 2021 - Springer
Large-scale molecular profiling studies in recent years have shown that central nervous
system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct …
system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct …
[HTML][HTML] Paediatric-type diffuse high-grade gliomas in the 5th CNS WHO Classification
F Gianno, I Giovannoni, B Cafferata… - Pathologica, 2022 - ncbi.nlm.nih.gov
As a relevant element of novelty, the fifth CNS WHO Classification highlights the distinctive
pathobiology underlying gliomas arising primarily in children by recognizing for the first time …
pathobiology underlying gliomas arising primarily in children by recognizing for the first time …
[HTML][HTML] Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene …
H Bogumil, M Sill, D Schrimpf, B Ismer, C Blume… - Acta …, 2023 - Springer
Glioneuronal tumors are a heterogenous group of CNS neoplasms that can be challenging
to accurately diagnose. Molecular methods are highly useful in classifying these tumors …
to accurately diagnose. Molecular methods are highly useful in classifying these tumors …
[HTML][HTML] Molecular pathology and clinical implications of diffuse glioma
R Chai, S Fang, B Pang, Y Liu, Y Wang… - Chinese Medical …, 2022 - journals.lww.com
The prognosis for diffusely infiltrating gliomas at World Health Organization (WHO) grade 2–
4 remains dismal due to their heterogeneity. The rapid development of genome-wide …
4 remains dismal due to their heterogeneity. The rapid development of genome-wide …
[HTML][HTML] Glioma stem cells in pediatric high-grade gliomas: from current knowledge to future perspectives
MA Da-Veiga, B Rogister, A Lombard, V Neirinckx… - Cancers, 2022 - mdpi.com
Simple Summary Pediatric high-grade glioma (pHGG) has a dismal prognosis in which the
younger the patient, the more restricted the treatments are, in regard to the incurred risks …
younger the patient, the more restricted the treatments are, in regard to the incurred risks …