Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Each heartbeat is initiated by the action potential, an electrical signal that depolarizes the
plasma membrane and activates a cycle of calcium influx via voltage-gated calcium …

Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic
augmentation of CaV1. 2 voltage-gated calcium channels,,–. However, this augmentation …

Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact
sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the …

The L-type Ca2+ channel Cav1. 2 controls multiple functions throughout the body including
heart rate and neuronal excitability. It is a key mediator of fight-or-flight stress responses …

Voltage‐gated potassium (KV) channels are key regulators of vascular smooth muscle
contractility and vascular tone, and thus have major influence on the microcirculation. KV …

Background: L-type CaV1. 2 channels undergo cooperative gating to regulate cell function,
although mechanisms are unclear. This study tests the hypothesis that phosphorylation of …

Diabetes affects millions of people worldwide. This devastating disease dramatically
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …

Although slow gastric emptying (gastroparesis) is a well-known complication of chronic
hyperglycemia in diabetes mellitus (DM), it recently has become clear that rapid gastric …

Impairment of vascular pathways of cerebral β-amyloid (Aβ) elimination contributes to
Alzheimer disease (AD). Vascular damage is commonly associated with diabetes. Here we …