Mechanisms and physiological implications of cooperative gating of clustered ion channels
Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …
Adrenergic regulation of calcium channels in the heart
Each heartbeat is initiated by the action potential, an electrical signal that depolarizes the
plasma membrane and activates a cycle of calcium influx via voltage-gated calcium …
plasma membrane and activates a cycle of calcium influx via voltage-gated calcium …
Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics
G Liu, A Papa, AN Katchman, SI Zakharov, D Roybal… - Nature, 2020 - nature.com
Increased cardiac contractility during the fight-or-flight response is caused by β-adrenergic
augmentation of CaV1. 2 voltage-gated calcium channels,,–. However, this augmentation …
augmentation of CaV1. 2 voltage-gated calcium channels,,–. However, this augmentation …
NPC1-dependent alterations in KV2.1–CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease
Lysosomes communicate through cholesterol transfer at endoplasmic reticulum (ER) contact
sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the …
sites. At these sites, the Niemann Pick C1 cholesterol transporter (NPC1) facilitates the …
Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the β2-adrenergic receptor in neurons
The L-type Ca2+ channel Cav1. 2 controls multiple functions throughout the body including
heart rate and neuronal excitability. It is a key mediator of fight-or-flight stress responses …
heart rate and neuronal excitability. It is a key mediator of fight-or-flight stress responses …
Regulation of voltage‐gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders
Voltage‐gated potassium (KV) channels are key regulators of vascular smooth muscle
contractility and vascular tone, and thus have major influence on the microcirculation. KV …
contractility and vascular tone, and thus have major influence on the microcirculation. KV …
Spatiotemporal Control of Vascular CaV1.2 by α1C S1928 Phosphorylation
M Martín-Aragón Baudel, VA Flores-Tamez… - Circulation …, 2022 - Am Heart Assoc
Background: L-type CaV1. 2 channels undergo cooperative gating to regulate cell function,
although mechanisms are unclear. This study tests the hypothesis that phosphorylation of …
although mechanisms are unclear. This study tests the hypothesis that phosphorylation of …
Cellular and molecular effects of hyperglycemia on ion channels in vascular smooth muscle
M Nieves-Cintrón, VA Flores-Tamez, T Le… - Cellular and Molecular …, 2021 - Springer
Diabetes affects millions of people worldwide. This devastating disease dramatically
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …
increases the risk of developing cardiovascular disorders. A hallmark metabolic abnormality …
Rapid gastric emptying in diabetes mellitus: Pathophysiology and clinical importance
RK Goyal, V Cristofaro, MP Sullivan - Journal of Diabetes and its …, 2019 - Elsevier
Although slow gastric emptying (gastroparesis) is a well-known complication of chronic
hyperglycemia in diabetes mellitus (DM), it recently has become clear that rapid gastric …
hyperglycemia in diabetes mellitus (DM), it recently has become clear that rapid gastric …
Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas
N Verma, GV Velmurugan, E Winford, H Coburn… - Communications …, 2023 - nature.com
Impairment of vascular pathways of cerebral β-amyloid (Aβ) elimination contributes to
Alzheimer disease (AD). Vascular damage is commonly associated with diabetes. Here we …
Alzheimer disease (AD). Vascular damage is commonly associated with diabetes. Here we …