Molecular pathogenesis of malignant mesothelioma

Y Sekido - Carcinogenesis, 2013 - academic.oup.com
Malignant mesothelioma (MM) is an aggressive tumor arising primarily from the pleural or
peritoneal cavities. It develops by asbestos exposure after a long latency, which is …

Genotoxicity and carcinogenicity risk of carbon nanotubes

S Toyokuni - Advanced Drug Delivery Reviews, 2013 - Elsevier
Novel materials are often commercialized without a complete assessment of the risks they
pose to human health because such assessments are costly and time-consuming; …

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

H Nagai, Y Okazaki, SH Chew… - Proceedings of the …, 2011 - National Acad Sciences
Multiwalled carbon nanotubes (MWCNTs) have the potential for widespread applications in
engineering and materials science. However, because of their needle-like shape and high …

Malignant mesothelioma as an oxidative stress-induced cancer: An update

SH Chew, S Toyokuni - Free Radical Biology and Medicine, 2015 - Elsevier
Malignant mesothelioma (MM) is a relatively rare cancer that occurs almost exclusively
following respiratory exposure to asbestos in humans. Its pathogenesis is closely associated …

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer

S Akatsuka, Y Yamashita, H Ohara, YT Liu, M Izumiya… - 2012 - journals.plos.org
Iron overload has been associated with carcinogenesis in humans. Intraperitoneal
administration of ferric nitrilotriacetate initiates a Fenton reaction in renal proximal tubules of …

Iron overload signature in chrysotile‐induced malignant mesothelioma

L Jiang, S Akatsuka, H Nagai, SH Chew… - The Journal of …, 2012 - Wiley Online Library
Exposure to asbestos is a risk for malignant mesothelioma (MM) in humans. Among the
commercially used types of asbestos (chrysotile, crocidolite, and amosite), the …

[HTML][HTML] Epidemiological and nonclinical studies investigating effects of iron in carcinogenesis—a critical review

Y Beguin, M Aapro, H Ludwig, L Mizzen… - Critical reviews in …, 2014 - Elsevier
The efficacy and tolerability of intravenous (iv) iron in managing cancer-related anemia and
iron deficiency has been clinically evaluated and reviewed recently. However, long-term …

Recent progress and perspectives on the mechanisms underlying Asbestos toxicity

A Kuroda - Genes and Environment, 2021 - Springer
Most cases of mesothelioma are known to result from exposure to asbestos fibers in the
environment or occupational ambient air. The following questions regarding asbestos …

Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis: shedding light on fiber entry mechanism

H Nagai, S Toyokuni - Cancer science, 2012 - Wiley Online Library
The emergence of nanotechnology represents an important milestone, as it opens the way
to a broad spectrum of applications for nanomaterials in the fields of engineering, industry …

Asbestos conceives Fe (II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium

F Ito, I Yanatori, Y Maeda, K Nimura, S Ito, T Hirayama… - Redox Biology, 2020 - Elsevier
Asbestos is still a social burden worldwide as a carcinogen causing malignant
mesothelioma. Whereas recent studies suggest that local iron reduction is a preventive …