Emerging evidence indicates that the detection and clearance of cancer cells via
phagocytosis induced by innate immune checkpoints play significant roles in tumor …

Transforming growth factor-β (TGF-β) signaling regulates multiple physiological processes,
such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides …

Background Therapeutic antibodies targeting programmed cell death protein 1 (PD-
1)/programmed death-ligand 1 (PD-L1) axis induce potent and durable anti-tumor …

Background Our previous work showed that the anti-TGF-β/PD-L1 bispecific antibody
YM101 effectively overcame anti-PD-L1 resistance in immune-excluded tumor models …

Sustained expression of programmed cell death receptor-1 (PD-1) is correlated with the
exhaustion of T cells, and blockade of the PD-1 pathway is an effective immunotherapeutic …

Background An increasing body of evidence has supported that long non-coding RNAs
(lncRNAs) can play as essential roles of various physiological process and pathological …

Simple Summary A clinical decision and study design investigating the level and extent of
angiogenesis modulation aimed at vascular normalization without rendering tissues hypoxic …

Immune checkpoint inhibitors are a class of antineoplastic therapies that unleash immune
cells to kill malignant cells. There are currently 7 medications that have been approved by …

Background Knowledge of immune cell phenotypes, function, and developmental trajectory
in acute myeloid leukemia (AML) microenvironment is essential for understanding …

Antibody-drug conjugates (ADCs) are a promising class of immunotherapies with the
potential to specifically target tumor cells and ameliorate the therapeutic index of cytotoxic …