NK cell-based cancer immunotherapy: from basic biology to clinical development

S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …

NK cells for cancer immunotherapy

N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …

'Off-the-shelf'allogeneic CAR T cells: development and challenges

S Depil, P Duchateau, SA Grupp, G Mufti… - Nature reviews Drug …, 2020 - nature.com
Autologous chimeric antigen receptor (CAR) T cells have changed the therapeutic
landscape in haematological malignancies. Nevertheless, the use of allogeneic CAR T cells …

CAR-NK cells for cancer immunotherapy: from bench to bedside

L Zhang, Y Meng, X Feng, Z Han - Biomarker Research, 2022 - Springer
Natural killer (NK) cells are unique innate immune cells and manifest rapid and potent
cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of …

Phase 1 clinical trial using mbIL21 ex vivo–expanded donor-derived NK cells after haploidentical transplantation

SO Ciurea, JR Schafer, R Bassett… - Blood, The Journal …, 2017 - ashpublications.org
Relapse has emerged as the most important cause of treatment failure after allogeneic
hematopoietic stem cell transplantation (HSCT). To test the hypothesis that natural killer …

Natural killer cells in cancer immunotherapy

JS Miller, LL Lanier - Annual review of cancer biology, 2019 - annualreviews.org
Natural killer (NK) cells have evolved to complement T and B cells in host defense against
pathogens and cancer. They recognize infected cells and tumors using a sophisticated array …

The long path of human placenta, and its derivatives, in regenerative medicine

AR Silini, A Cargnoni, M Magatti, S Pianta… - … in bioengineering and …, 2015 - frontiersin.org
In the 1800s, a baby born with a caul, a remnant of the amniotic sack or fetal membranes,
was thought to be lucky, special, or protected. Over time, fetal membranes lost their …

Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models

F Otegbeye, E Ojo, S Moreton, N Mackowski, DA Lee… - PloS one, 2018 - journals.plos.org
Natural killer cells harnessed from healthy individuals can be expanded ex vivo using
various platforms to produce large doses for adoptive transfer into cancer patients. During …

Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors

F Ghaedrahmati, N Esmaeil… - Cancer …, 2023 - Wiley Online Library
Natural killer (NK) cells are unique innate immune cells that mediate anti‐viral and anti‐
tumor responses. Thus, they might hold great potential for cancer immunotherapy. NK cell …

Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy

MJAJ Huijskens, M Walczak, S Sarkar, F Atrafi… - Cytotherapy, 2015 - Elsevier
Background aims Natural killer (NK) cell–based immunotherapy is a promising treatment for
a variety of malignancies. However, generating sufficient cell numbers for therapy remains a …