NK cell-based cancer immunotherapy: from basic biology to clinical development
S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …
immune activation against abnormal cells. Different from events required for T cell activation …
NK cells for cancer immunotherapy
N Shimasaki, A Jain, D Campana - Nature reviews Drug discovery, 2020 - nature.com
Natural killer (NK) cells can swiftly kill multiple adjacent cells if these show surface markers
associated with oncogenic transformation. This property, which is unique among immune …
associated with oncogenic transformation. This property, which is unique among immune …
'Off-the-shelf'allogeneic CAR T cells: development and challenges
Autologous chimeric antigen receptor (CAR) T cells have changed the therapeutic
landscape in haematological malignancies. Nevertheless, the use of allogeneic CAR T cells …
landscape in haematological malignancies. Nevertheless, the use of allogeneic CAR T cells …
CAR-NK cells for cancer immunotherapy: from bench to bedside
L Zhang, Y Meng, X Feng, Z Han - Biomarker Research, 2022 - Springer
Natural killer (NK) cells are unique innate immune cells and manifest rapid and potent
cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of …
cytotoxicity for cancer immunotherapy and pathogen removal without the requirement of …
Phase 1 clinical trial using mbIL21 ex vivo–expanded donor-derived NK cells after haploidentical transplantation
Relapse has emerged as the most important cause of treatment failure after allogeneic
hematopoietic stem cell transplantation (HSCT). To test the hypothesis that natural killer …
hematopoietic stem cell transplantation (HSCT). To test the hypothesis that natural killer …
Natural killer cells in cancer immunotherapy
JS Miller, LL Lanier - Annual review of cancer biology, 2019 - annualreviews.org
Natural killer (NK) cells have evolved to complement T and B cells in host defense against
pathogens and cancer. They recognize infected cells and tumors using a sophisticated array …
pathogens and cancer. They recognize infected cells and tumors using a sophisticated array …
The long path of human placenta, and its derivatives, in regenerative medicine
In the 1800s, a baby born with a caul, a remnant of the amniotic sack or fetal membranes,
was thought to be lucky, special, or protected. Over time, fetal membranes lost their …
was thought to be lucky, special, or protected. Over time, fetal membranes lost their …
Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models
Natural killer cells harnessed from healthy individuals can be expanded ex vivo using
various platforms to produce large doses for adoptive transfer into cancer patients. During …
various platforms to produce large doses for adoptive transfer into cancer patients. During …
Targeting immune checkpoints: how to use natural killer cells for fighting against solid tumors
F Ghaedrahmati, N Esmaeil… - Cancer …, 2023 - Wiley Online Library
Natural killer (NK) cells are unique innate immune cells that mediate anti‐viral and anti‐
tumor responses. Thus, they might hold great potential for cancer immunotherapy. NK cell …
tumor responses. Thus, they might hold great potential for cancer immunotherapy. NK cell …
Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy
MJAJ Huijskens, M Walczak, S Sarkar, F Atrafi… - Cytotherapy, 2015 - Elsevier
Background aims Natural killer (NK) cell–based immunotherapy is a promising treatment for
a variety of malignancies. However, generating sufficient cell numbers for therapy remains a …
a variety of malignancies. However, generating sufficient cell numbers for therapy remains a …