In the early 1980s, the first-published reports of baculovirus-mediated foreign gene
expression stimulated great interest in the use of baculovirus–insect cell systems for …

Insect cells (IC) and particularly lepidopteran cells are an attractive alternative to mammalian
cells for biomanufacturing. Insect cell culture, coupled with the lytic expression capacity of …

Scalable methods of recombinant adeno-associated virus (rAAV) production have gained
much recent interest as the field of rAAV-mediated gene therapy approaches the clinic. In …

Biological control uses living organisms like bacteria, fungi, nematodes, insects or mites
(including viruses) for the control of weeds or pests and diseases of crop plants. Information …

In 1982 E. coli produced human insulin, the world's first recombinant DNA drug, was
approved by the FDA. Since this historical event, remarkable progress has been made in …

Obtaining high quantities of a specific protein directly from native sources is often
challenging, particularly when dealing with human proteins. To overcome this obstacle …

The aim of this study was the development of a scalable production process for high titer (10
8 pfu/mL and above) recombinant baculovirus stocks with low cell line-derived impurities for …

We review the properties and uses of cell lines in Drosophila research, emphasizing the
variety of lines, the large body of genomic and transcriptional data available for many of the …

Cell culture for the purposes of viral vaccine cultivation is reviewed from the perspective of
the industrial practitioner. This article covers the mechanics of virus production, followed by …

Insect cells can be used for the efficient production of heterologous proteins. The
baculovirus expression vector system (BEVS) in Spodoptera frugiperda cells and the stable …