Cell surface receptors and their interactions play a central role in physiological and
pathological signaling. Despite its clinical relevance, the immunoglobulin superfamily (IgSF) …

Infectious and epidemic diseases induced by bacteria have historically caused great
distress to people, and have even resulted in a large number of deaths worldwide. At …

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions
globally, with increasing urban cases outside of Latin America. Treatment is based on two …

Bromodomains are structural folds present in all eukaryotic cells that bind to other proteins
recognizing acetylated lysines. Most proteins with bromodomains are part of nuclear …

Lymphatic filariasis is caused by parasitic nematodes and is a leading cause of disability
worldwide. Many filarial worms contain the bacterium Wolbachia as an obligate …

This chapter outlines the usefulness of nematodes, such as entomophilic nematodes, as
biological models of animal-microbe symbioses and their potential to expand our …

Nematode parasites enter their definitive host at the developmentally arrested infectious
larval stage (iL3), and the ligand-dependent nuclear receptor DAF-12 contributes to trigger …

Genomics, transcriptomics, and proteomics have significantly advanced our understanding
of obligately host-associated microbes, where interrogation of the biology is often limited by …

Background Lymphatic Filariasis (LF) is a neglected tropical disease affecting more than
882 million people in 44 countries of the world. A multi-epitope prophylactic/therapeutic …

Wolbachia is a genus containing obligate, intracellular endosymbionts with arthropod and
nematode hosts. Numerous studies have identified differentially expressed transcripts in …