Mechanical principles of nuclear shaping and positioning
TP Lele, RB Dickinson, GG Gundersen - Journal of Cell Biology, 2018 - rupress.org
Positioning and shaping the nucleus represents a mechanical challenge for the migrating
cell because of its large size and resistance to deformation. Cells shape and position the …
cell because of its large size and resistance to deformation. Cells shape and position the …
The role of stiffness in cell reprogramming: a potential role for biomaterials in inducing tissue regeneration
M d'Angelo, E Benedetti, MG Tupone, M Catanesi… - Cells, 2019 - mdpi.com
The mechanotransduction is the process by which cells sense mechanical stimuli such as
elasticity, viscosity, and nanotopography of extracellular matrix and translate them into …
elasticity, viscosity, and nanotopography of extracellular matrix and translate them into …
Multiplexed 3D atlas of state transitions and immune interaction in colorectal cancer
Advanced solid cancers are complex assemblies of tumor, immune, and stromal cells
characterized by high intratumoral variation. We use highly multiplexed tissue imaging, 3D …
characterized by high intratumoral variation. We use highly multiplexed tissue imaging, 3D …
A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation
Mutations in ARID1A rank among the most common molecular aberrations in human cancer.
However, oncogenic consequences of ARID1A mutation in human cells remain poorly …
However, oncogenic consequences of ARID1A mutation in human cells remain poorly …
Graph-based autoencoder integrates spatial transcriptomics with chromatin images and identifies joint biomarkers for Alzheimer's disease
Tissue development and disease lead to changes in cellular organization, nuclear
morphology, and gene expression, which can be jointly measured by spatial transcriptomic …
morphology, and gene expression, which can be jointly measured by spatial transcriptomic …
HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics
Chromatin, which consists of DNA and associated proteins, contains genetic information and
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …
is a mechanical component of the nucleus. Heterochromatic histone methylation controls …
Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei
Topographical cues on cells can, through contact guidance, alter cellular plasticity and
accelerate the regeneration of cultured tissue. Here we show how changes in the nuclear …
accelerate the regeneration of cultured tissue. Here we show how changes in the nuclear …
Unsupervised representation learning of chromatin images identifies changes in cell state and tissue organization in DCIS
Ductal carcinoma in situ (DCIS) is a pre-invasive tumor that can progress to invasive breast
cancer, a leading cause of cancer death. We generate a large-scale tissue microarray …
cancer, a leading cause of cancer death. We generate a large-scale tissue microarray …
Effect of nuclear stiffness on cell mechanics and migration of human breast cancer cells
T Fischer, A Hayn, CT Mierke - Frontiers in cell and developmental …, 2020 - frontiersin.org
The migration and invasion of cancer cells through 3D confined extracellular matrices is
coupled to cell mechanics and the mechanics of the extracellular matrix. Cell mechanics is …
coupled to cell mechanics and the mechanics of the extracellular matrix. Cell mechanics is …
Nucleophagy: from homeostasis to disease
ME Papandreou, N Tavernarakis - Cell Death & Differentiation, 2019 - nature.com
Nuclear abnormalities are prominent in degenerative disease and progeria syndromes.
Selective autophagy of organelles is instrumental in maintaining cell homeostasis and …
Selective autophagy of organelles is instrumental in maintaining cell homeostasis and …