Lectins and lectibodies: potential promising antiviral agents
In nature, lectins are widely dispersed proteins that selectively recognize and bind to
carbohydrates and glycoconjugates via reversible bonds at specific binding sites. Many viral …
carbohydrates and glycoconjugates via reversible bonds at specific binding sites. Many viral …
Antiviral lectins: Selective inhibitors of viral entry
CA Mitchell, K Ramessar, BR O'Keefe - Antiviral research, 2017 - Elsevier
Many natural lectins have been reported to have antiviral activity. As some of these have
been put forward as potential development candidates for preventing or treating viral …
been put forward as potential development candidates for preventing or treating viral …
Emerging antibody products and Nicotiana manufacturing
KJ Whaley, A Hiatt, L Zeitlin - Human vaccines, 2011 - Taylor & Francis
Antibody based products are not widely available to address multiple global health
challenges due to high costs, limited manufacturing capacity, and long manufacturing lead …
challenges due to high costs, limited manufacturing capacity, and long manufacturing lead …
Targeting cell entry of enveloped viruses as an antiviral strategy
E Teissier, F Penin, EI Pécheur - Molecules, 2010 - mdpi.com
The entry of enveloped viruses into their host cells involves several successive steps, each
one being amenable to therapeutic intervention. Entry inhibitors act by targeting viral and/or …
one being amenable to therapeutic intervention. Entry inhibitors act by targeting viral and/or …
N-Glycosylation of cholera toxin B subunit in Nicotiana benthamiana: impacts on host stress response, production yield and vaccine potential
KT Hamorsky, JC Kouokam, JM Jurkiewicz… - Scientific Reports, 2015 - nature.com
Plant-based transient overexpression systems enable rapid and scalable production of
subunit vaccines. Previously, we have shown that cholera toxin B subunit (CTB), an oral …
subunit vaccines. Previously, we have shown that cholera toxin B subunit (CTB), an oral …
Preventing mucosal HIV transmission with topical microbicides: challenges and opportunities
F Hladik, GF Doncel - Antiviral research, 2010 - Elsevier
A combination of prevention and treatment modalities will be needed to successfully control
the global spread of HIV. Microbicides, drug products topically applied to mucosal surfaces …
the global spread of HIV. Microbicides, drug products topically applied to mucosal surfaces …
Environment Control to Improve Recombinant Protein Yields in Plants Based on Agrobacterium-Mediated Transient Gene Expression
Agrobacterium-mediated transient expression systems enable plants to produce a wide
range of recombinant proteins on a rapid timescale. To achieve economically feasible …
range of recombinant proteins on a rapid timescale. To achieve economically feasible …
Recent advances on anti-HIV vaginal delivery systems development
SG Antimisiaris, S Mourtas - Advanced drug delivery reviews, 2015 - Elsevier
A review of the recent outcomes regarding technologies to prevent vaginal transmission of
HIV, mainly by using antiretroviral (ARV) drugs formulated as microbicides. An introduction …
HIV, mainly by using antiretroviral (ARV) drugs formulated as microbicides. An introduction …
Antitumor activity of a lectibody targeting cancer-associated high-mannose glycans
Aberrant protein glycosylation is a hallmark of cancer, but few drugs targeting cancer
glycobiomarkers are currently available. Here, we showed that a lectibody consisting of the …
glycobiomarkers are currently available. Here, we showed that a lectibody consisting of the …
Rapid and scalable plant-based production of a cholera toxin B subunit variant to aid in mass vaccination against cholera outbreaks
KT Hamorsky, JC Kouokam, LJ Bennett… - PLoS neglected …, 2013 - journals.plos.org
Introduction Cholera toxin B subunit (CTB) is a component of an internationally licensed oral
cholera vaccine. The protein induces neutralizing antibodies against the holotoxin, the …
cholera vaccine. The protein induces neutralizing antibodies against the holotoxin, the …