Induced pluripotent stem cells and their use in human models of disease and development
P Karagiannis, K Takahashi, M Saito… - Physiological …, 2019 - journals.physiology.org
The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …
A decade of transcription factor-mediated reprogramming to pluripotency
K Takahashi, S Yamanaka - Nature reviews Molecular cell biology, 2016 - nature.com
The past 10 years have seen great advances in our ability to manipulate cell fate, including
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …
the induction of pluripotency in vitro to generate induced pluripotent stem cells (iPSCs). This …
Single-cell transcriptional diversity is a hallmark of developmental potential
GS Gulati, SS Sikandar, DJ Wesche, A Manjunath… - Science, 2020 - science.org
Single-cell RNA sequencing (scRNA-seq) is a powerful approach for reconstructing cellular
differentiation trajectories. However, inferring both the state and direction of differentiation is …
differentiation trajectories. However, inferring both the state and direction of differentiation is …
[HTML][HTML] Caspase-1 and Gasdermin D afford the optimal targets with distinct switching strategies in NLRP1b inflammasome-induced cell death
Inflammasomes are essential complexes of innate immune system, which form the first line
of host defense against pathogens. Mounting evidence accumulates that inflammasome …
of host defense against pathogens. Mounting evidence accumulates that inflammasome …
The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution
INTRODUCTION Metazoan development represents a big jump in complexity compared
with unicellular life in two aspects: cell-type differentiation and cell spatial organization. In …
with unicellular life in two aspects: cell-type differentiation and cell spatial organization. In …
Identification of methylation haplotype blocks aids in deconvolution of heterogeneous tissue samples and tumor tissue-of-origin mapping from plasma DNA
Adjacent CpG sites in mammalian genomes can be co-methylated owing to the processivity
of methyltransferases or demethylases, yet discordant methylation patterns have also been …
of methyltransferases or demethylases, yet discordant methylation patterns have also been …
m6A RNA modification controls cell fate transition in mammalian embryonic stem cells
Summary N6-methyl-adenosine (m 6 A) is the most abundant modification on messenger
RNAs and is linked to human diseases, but its functions in mammalian development are …
RNAs and is linked to human diseases, but its functions in mammalian development are …
H3K9me3-dependent heterochromatin: barrier to cell fate changes
Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell
resource, with potential for studying disease and use in regenerative medicine. However …
resource, with potential for studying disease and use in regenerative medicine. However …
[HTML][HTML] Stability of the hybrid epithelial/mesenchymal phenotype
Abstract Epithelial-to-Mesenchymal Transition (EMT) and its reverse–Mesenchymal to
Epithelial Transition (MET)–are hallmarks of cellular plasticity during embryonic …
Epithelial Transition (MET)–are hallmarks of cellular plasticity during embryonic …