Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …

Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation
in all organisms. Genetic variation in regulatory regions has been connected with diseases …

INTRODUCTION Thalidomide, lenalidomide, and pomalidomide are clinically approved
therapies for the treatment of multiple myeloma and other hematologic malignancies. These …

In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of
thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and …

Abiotic stresses such as drought and salinity are major environmental factors that limit crop
yields. Unraveling the molecular mechanisms underlying abiotic stress resistance is crucial …

Adult T cell leukemia/lymphoma (ATL) is a peripheral T cell neoplasm of largely unknown
genetic basis, associated with human T cell leukemia virus type-1 (HTLV-1) infection. Here …

Zinc has been described as the 'calcium of the twenty-first century'. Zinc-based degradable
biomaterials have recently emerged thanks to their intrinsic physiological relevance …

Gene expression is regulated by transcription factors (TFs), proteins that recognize short
DNA sequence motifs,,. Such sequences are very common in the human genome, and an …

Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …