Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis

W Jia, G Xie, W Jia - Nature reviews Gastroenterology & hepatology, 2018 - nature.com
Emerging evidence points to a strong association between the gut microbiota and the risk,
development and progression of gastrointestinal cancers such as colorectal cancer (CRC) …

Carotenoid-loaded nanocarriers: A comprehensive review

A Rehman, Q Tong, SM Jafari, E Assadpour… - Advances in colloid and …, 2020 - Elsevier
Carotenoids retain plenty of health benefits and attracting much attention recently, but they
have less resistance to processing stresses, easily oxidized and chemically unstable …

[HTML][HTML] The influence of the gut microbiota on the bioavailability of oral drugs

X Zhang, Y Han, W Huang, M Jin, Z Gao - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Due to its safety, convenience, low cost and good compliance, oral administration attracts
lots of attention. However, the efficacy of many oral drugs is limited to their unsatisfactory …

[HTML][HTML] Bile acids and their derivatives as potential modifiers of drug release and pharmacokinetic profiles

N Pavlović, S Goločorbin-Kon, M Ðanić… - Frontiers in …, 2018 - frontiersin.org
Bile acids have received considerable interest in the drug delivery research due to their
peculiar physicochemical properties and biocompatibility. The main advantage of bile acids …

Characterization of human duodenal fluids in fasted and fed state conditions

D Riethorst, R Mols, G Duchateau, J Tack… - Journal of …, 2016 - Elsevier
This work provides an elaborate characterization of human intestinal fluids (HIF) collected in
fasted-and fed-state conditions. HIF from 20 healthy volunteers (10 M/F) were aspirated by …

In vivo methods for drug absorption–comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API …

E Sjögren, B Abrahamsson, P Augustijns… - European Journal of …, 2014 - Elsevier
This review summarizes the current knowledge on anatomy and physiology of the human
gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and …

Safety of probiotics: functional fruit beverages and nutraceuticals

I Žuntar, Z Petric, D Bursać Kovačević, P Putnik - Foods, 2020 - mdpi.com
Over the last decade, fruit juice consumption has increased. Their rise in popularity can be
attributed to the belief that they are a quick way to consuming a dietary portion of fruit …

Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs

CAS Bergström, R Holm, SA Jørgensen… - European Journal of …, 2014 - Elsevier
Preformulation measurements are used to estimate the fraction absorbed in vivo for orally
administered compounds and thereby allow an early evaluation of the need for enabling …

Absorption-enhancing effects of bile salts

E Moghimipour, A Ameri, S Handali - Molecules, 2015 - mdpi.com
Bile salts are ionic amphiphilic compounds with a steroid skeleton. Among the most
important physiological properties of bile salts are lipid transport by solubilization and …

On the role of bile salts in the digestion of emulsified lipids

A Sarkar, A Ye, H Singh - Food hydrocolloids, 2016 - Elsevier
The objective of this study was to understand quantitatively the role that bile salts play in the
digestion of emulsified lipids. The behaviours of digestion by pancreatin (1.6 mg/mL) of …