Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …

An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …

Abstract BCR:: ABL1-negative myeloproliferative neoplasms (MPNs) are clonal diseases
originating from a single hematopoietic stem cell that cause excessive production of mature …

Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative
neoplasms with variable risk of evolution into post-PV and post-ET myelofibrosis, from now …

Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by
aberrant hematopoietic proliferation and an increased tendency toward leukemic …

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy with a poor
overall survival. Reactive oxygen species (ROS) have been shown to be elevated in a wide …

Polycythemia vera (PV) is a hematopoietic stem cell neoplasm defined by activating somatic
mutations in the JAK2 gene and characterized clinically by overproduction of red blood cells …

Myeloproliferative neoplasms (MPN) include three main entities: Polycythemia Vera (PV),
Essential Thrombocythemia (ET), and Myelofibrosis (MF). MPN represent a unique model of …

Myeloproliferative neoplasms are clonal disorders characterized by the presence of several
gene mutations associated with particular hematologic parameters, clinical evolution, and …

Oxidative stress is related to ageing and degenerative diseases, including cancer. However,
a moderate amount of reactive oxygen species (ROS) is required for the regulation of …