[HTML][HTML] Considerations for polymers used in ocular drug delivery

MM Allyn, RH Luo, EB Hellwarth… - Frontiers in …, 2022 - frontiersin.org
Purpose: Age-related eye diseases are becoming more prevalent. A notable increase has
been seen in the most common causes including glaucoma, age-related macular …

Ocular drug delivery to the retina: current innovations and future perspectives

HM Kim, SJ Woo - Pharmaceutics, 2021 - mdpi.com
Treatment options for retinal diseases, such as neovascular age-related macular
degeneration, diabetic retinopathy, and retinal vascular disorders, have markedly expanded …

Dexamethasone: insights into pharmacological aspects, therapeutic mechanisms, and delivery systems

VS Madamsetty, R Mohammadinejad… - ACS biomaterials …, 2022 - ACS Publications
Dexamethasone (DEX) has been widely used to treat a variety of diseases, including
autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19 …

Polymeric long-acting drug delivery systems (LADDS) for treatment of chronic diseases: Inserts, patches, wafers, and implants

H Abdelkader, Z Fathalla, A Seyfoddin… - Advanced drug delivery …, 2021 - Elsevier
Non-oral long-acting drug delivery systems (LADDS) encompass a range of technologies for
precisely delivering drug molecules into target tissues either through the systemic circulation …

Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

S Li, L Chen, Y Fu - Journal of Nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …

Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy

J Wei, J Mu, Y Tang, D Qin, J Duan, A Wu - Journal of nanobiotechnology, 2023 - Springer
Ophthalmic inflammatory diseases, including conjunctivitis, keratitis, uveitis, scleritis, and
related conditions, pose considerable challenges to effective management and treatment …

[HTML][HTML] MiRNA 24-3p-rich exosomes functionalized DEGMA-modified hyaluronic acid hydrogels for corneal epithelial healing

X Sun, W Song, L Teng, Y Huang, J Liu, Y Peng, X Lu… - Bioactive Materials, 2023 - Elsevier
The damage of corneal epithelium may lead to the formation of irreversible corneal opacities
and even blindness. The migration rate of corneal epithelial cells directly affects corneal …

Treatment of non-infectious corneal injury: review of diagnostic agents, therapeutic medications, and future targets

DH Dang, KM Riaz, D Karamichos - Drugs, 2022 - Springer
Corneal injuries can occur secondary to traumatic, chemical, inflammatory, metabolic,
autoimmune, and iatrogenic causes. Ocular infection may frequently occur concurrent to …

Reverse engineering the Ozurdex dexamethasone intravitreal implant

MA Costello, J Liu, Y Wang, B Qin, X Xu, Q Li… - International Journal of …, 2023 - Elsevier
Ozurdex is a biodegradable implant formulated for sustained-release delivery of the
corticosteroid dexamethasone to the posterior segment of the eye. The small, rod-shaped …

Hyaluronic acid–PVA films for the simultaneous delivery of dexamethasone and levofloxacin to ocular tissues

M Ghezzi, I Ferraboschi, A Fantini, S Pescina… - International Journal of …, 2023 - Elsevier
Ocular drug delivery is challenging due to the poor drug penetration across ocular barriers
and short retention time of the formulation at the application site. Films, applied as inserts or …