Glucocorticoid hormones were discovered to have use as potent anti-inflammatory and
immunosuppressive therapeutics in the 1940s and their continued use and development …

Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging
role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D) …

摘要糖皮质激素诱导的高血糖是一个常见的医疗问题, 它使患者频繁至急诊室就诊,
并延长入院及住院时间, 除此之外还有众所周知的高血糖导致死亡率增加的问题. 然而 …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Metabolomics, or the comprehensive profiling of small molecule metabolites in cells, tissues,
or whole organisms, has undergone a rapid technological evolution in the past two decades …

OBJECTIVE To conduct a systematic review of cross-sectional and prospective human
studies evaluating metabolite markers identified using high-throughput metabolomics …

Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Emerging technologies allow the high-throughput profiling of metabolic status from a blood
specimen (metabolomics). We investigated whether metabolite profiles could predict the …

Fatty acids (FA) and FA-derived metabolites have long been implicated in the development
of insulin resistance and type 2 diabetes. Surprisingly, application of metabolomics …