The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

EMT, MET, plasticity, and tumor metastasis

B Bakir, AM Chiarella, JR Pitarresi, AK Rustgi - Trends in cell biology, 2020 - cell.com
Cancer cell identity and plasticity are required in transition states, such as epithelial–
mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET), in primary …

Distinct contributions of partial and full EMT to breast cancer malignancy

F Lüönd, N Sugiyama, R Bill, L Bornes, C Hager… - Developmental cell, 2021 - cell.com
Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-
differentiation where cancer cells transit between various stages of an EMT continuum …

Guidelines and definitions for research on epithelial–mesenchymal transition

J Yang, P Antin, G Berx, C Blanpain… - … reviews Molecular cell …, 2020 - nature.com
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …

Pancreatic cancer stroma: an update on therapeutic targeting strategies

AN Hosein, RA Brekken, A Maitra - Nature reviews Gastroenterology & …, 2020 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …

TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis

Y Hao, D Baker, P Ten Dijke - International journal of molecular sciences, 2019 - mdpi.com
Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …

EMT transition states during tumor progression and metastasis

I Pastushenko, C Blanpain - Trends in cell biology, 2019 - cell.com
Epithelial–mesenchymal transition (EMT) is a process in which epithelial cells acquire
mesenchymal features. In cancer, EMT is associated with tumor initiation, invasion …

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

A Dongre, RA Weinberg - Nature reviews Molecular cell biology, 2019 - nature.com
Epithelial–mesenchymal transition (EMT) is a cellular programme that is known to be crucial
for embryogenesis, wound healing and malignant progression. During EMT, cell–cell and …

Epithelial-mesenchymal plasticity in cancer progression and metastasis

W Lu, Y Kang - Developmental cell, 2019 - cell.com
Epithelial-to-mesenchymal transition (EMT) and its reversed process, mesenchymal-to-
epithelial transition (MET), are fundamental processes in embryonic development and tissue …

Identification of the tumour transition states occurring during EMT

I Pastushenko, A Brisebarre, A Sifrim, M Fioramonti… - Nature, 2018 - nature.com
In cancer, the epithelial-to-mesenchymal transition (EMT) is associated with tumour
stemness, metastasis and resistance to therapy. It has recently been proposed that, rather …