Improving quality of science through better animal welfare: the NC3Rs strategy

MJ Prescott, K Lidster - Lab animal, 2017 - nature.com
Good animal welfare is linked to the quality of research data derived from laboratory
animals, their validity as models of human disease, the number of animals required to reach …

[HTML][HTML] The multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of disease

ML Graham, MJ Prescott - European journal of pharmacology, 2015 - Elsevier
Ethics on animal use in science in Western society is based on utilitarianism, weighing the
harms and benefits to the animals involved against those of the intended human …

Ethics in animal-based research

D Gross, RH Tolba - European Surgical Research, 2015 - karger.com
In recent years, there have been a number of new demands and regulations which have
reignited the discussion on ethics in animal-based research. In the light of this development …

Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs)

N Burden, K Chapman, F Sewell… - Journal of the American …, 2015 - ingentaconnect.com
The National Centre for the Replacement, Refinement, and Reduction of Animals in
Research (NC3Rs) is an independent scientific organization that is based in the United …

[HTML][HTML] Opportunities for improving animal welfare in rodent models of epilepsy and seizures

K Lidster, JG Jefferys, I Blümcke, V Crunelli… - Journal of neuroscience …, 2016 - Elsevier
Animal models of epilepsy and seizures, mostly involving mice and rats, are used to
understand the pathophysiology of the different forms of epilepsy and their comorbidities, to …

Standardized automated training of rhesus monkeys for neuroscience research in their housing environment

M Berger, A Calapai, V Stephan… - Journal of …, 2018 - journals.physiology.org
Teaching nonhuman primates the complex cognitive behavioral tasks that are central to
cognitive neuroscience research is an essential and challenging endeavor. It is crucial for …

[HTML][HTML] International primate neuroscience research regulation, public engagement and transparency opportunities

AS Mitchell, R Hartig, MA Basso, W Jarrett, S Kastner… - Neuroimage, 2021 - Elsevier
Scientific excellence is a necessity for progress in biomedical research. As research
becomes ever more international, establishing international collaborations will be key to …

The indispensable contribution of nonhuman primates to biomedical research

S Treue, R Lemon - Nonhuman Primate Welfare: From History, Science …, 2023 - Springer
Research in nonhuman primates is one of the cornerstones of modern biomedical research.
This approach, while quantitatively contributing only a very small component to biomedical …

Mixed‐complexity artificial grammar learning in humans and macaque monkeys: evaluating learning strategies

B Wilson, K Smith, CI Petkov - European Journal of …, 2015 - Wiley Online Library
Artificial grammars (AG) can be used to generate rule‐based sequences of stimuli. Some of
these can be used to investigate sequence‐processing computations in non‐human …

Assessment of stress responses in rhesus macaques (Macaca mulatta) to daily routine procedures in system neuroscience based on salivary cortisol concentrations

D Pfefferle, S Plümer, L Burchardt, S Treue, A Gail - PloS one, 2018 - journals.plos.org
Non-human primates participating in neurophysiological research are exposed to potentially
stressful experimental procedures, such as dietary control protocols, surgical implants and …