After an initial period of recovery, human neurological injury has long been thought to be
static. In order to improve quality of life for those suffering from stroke, spinal cord injury, or …

Parkinson's disease (PD) is a neurodegenerative disease that affects more than 1% of
people over the age of 60. The principal feature of this disease is the progressive loss of …

DBS of the medial forebrain bundle (MFB) has been investigated clinically in major
depressive disorder patients with rapid and long-term reduction of symptoms. In the context …

Preclinical and clinical evidence suggests that depression might be associated with a
dysfunction in the reward/motivation circuitry. Deep brain stimulation (DBS) of the …

Inhibitors of cell cycle proteins are known to reduce glial activation and to be neuroprotective
in a number of settings. In the context of intracerebral grafting, glial activation is documented …

Restorative therapy concepts, such as cell based therapies aim to restitute impaired
neurotransmission in neurodegenerative diseases. New strategies to enhance grafted cell …

Over the last two decades deep brain stimulation (DBS) has become a widely used
therapeutic alternative for a variety of neurological and psychiatric diseases. The extensive …

Traumatic spinal cord injury is a major cause of disability for which there are currently no
fully effective treatments. Recent studies using epidural electrical stimulation have shown …

Neuropathic pain after spinal cord injury (SCI) is a complex condition that responds poorly to
usual treatments. Cell transplantation represents a promising therapy; nevertheless, the …

Purpose/aim: Neuropathic pain following spinal cord injury (SCI) has a tremendous impact
on patient's quality of life, and frequently is the most limiting aspect of the disease. In view of …