Poloxamer 188 (p188) as a membrane resealing reagent in biomedical applications

JG Moloughney, N Weisleder - Recent patents on …, 2012 - ingentaconnect.com
Maintenance of the integrity of the plasma membrane is essential for maintenance of cellular
function and prevention of cell death. Since the plasma membrane is frequently exposed to …

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

EM Houang, YY Sham, FS Bates, JM Metzger - Skeletal muscle, 2018 - Springer
The scientific premise, design, and structure-function analysis of chemical-based muscle
membrane stabilizing block copolymers are reviewed here for applications in striated …

Enhancing the stabilization potential of lyophilization for extracellular vesicles

E Trenkenschuh, M Richter, E Heinrich… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EV) are an emerging technology as immune therapeutics and drug
delivery vehicles. However, EVs are usually stored at− 80° C which limits potential clinical …

Surfactant-free production of biomimetic giant unilamellar vesicles using PDMS-based microfluidics

N Yandrapalli, J Petit, O Bäumchen… - Communications …, 2021 - nature.com
Microfluidic production of giant lipid vesicles presents a paradigm-shift in the development of
artificial cells. While production is high-throughput and the lipid vesicles are mono-disperse …

Elevated concentrations cause upright alpha-synuclein conformation at lipid interfaces

SJ Roeters, K Strunge, KB Pedersen… - Nature …, 2023 - nature.com
The amyloid aggregation of α-synuclein (α S), related to Parkinson's disease, can be
catalyzed by lipid membranes. Despite the importance of lipid surfaces, the 3D-structure and …

The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells

B He, P Lin, Z Jia, W Du, W Qu, L Yuan, W Dai… - Biomaterials, 2013 - Elsevier
As the primary physiological barrier, intestinal epithelial cells regulate the transportation of
oral therapeutic agents including nanomedicines which significantly improves the …

[HTML][HTML] Comparing experimental and simulated pressure-area isotherms for DPPC

SL Duncan, RG Larson - Biophysical journal, 2008 - cell.com
Although pressure-area isotherms are commonly measured for lipid monolayers, it is not
always appreciated how much they can vary depending on experimental factors. Here, we …

Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake

X Li, D Chen, C Le, C Zhu, Y Gan… - International journal …, 2011 - Taylor & Francis
Background The aim of this study was to investigate the intestinal mucus-penetrating
properties and intestinal cellular uptake of two types of liposomes modified by Pluronic F127 …

Intestinal mucosa permeability following oral insulin delivery using core shell corona nanolipoparticles

X Li, S Guo, C Zhu, Q Zhu, Y Gan, J Rantanen… - Biomaterials, 2013 - Elsevier
Chitosan nanoparticles (NC) have excellent capacity for protein entrapment, favorable
epithelial permeability, and are regarded as promising nanocarriers for oral protein delivery …

[HTML][HTML] Lipid headgroup discrimination by antimicrobial peptide LL-37: insight into mechanism of action

F Neville, M Cahuzac, O Konovalov, Y Ishitsuka… - Biophysical journal, 2006 - cell.com
Interaction of the human antimicrobial peptide LL-37 with lipid monolayers has been
investigated by a range of complementary techniques including pressure-area isotherms …