A mini review on isatin, an anticancer scaffold with potential activities against neglected tropical diseases (NTDs)
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …
therapeutic fragments in drug design and development. The template has turned out to be …
Target Identification in Anti-Tuberculosis Drug Discovery
R Capela, R Félix, M Clariano, D Nunes… - International Journal of …, 2023 - mdpi.com
Mycobacterium tuberculosis (Mtb) is the etiological agent of tuberculosis (TB), a disease
that, although preventable and curable, remains a global epidemic due to the emergence of …
that, although preventable and curable, remains a global epidemic due to the emergence of …
Microencapsulation and Bioaccessibility of Phenolic Compounds of Vaccinium Leaf Extracts
In recent years, Vaccinium spp.(bilberry-VMT, lingonberry-VVIT, and blueberry-VCS) have
sparked particular interest for their prospective health benefits. The latest investigations …
sparked particular interest for their prospective health benefits. The latest investigations …
Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis
B Zhan, Y Gao, W Gao, Y Li, Z Li, Q Qi, X Lan… - Communications …, 2022 - nature.com
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is the second-deadliest
infectious disease worldwide. Emerging evidence shows that the elongation factor EF-Tu …
infectious disease worldwide. Emerging evidence shows that the elongation factor EF-Tu …
Recent advances in host-directed therapies for tuberculosis and malaria
KC Matteucci, AAS Correa, DL Costa - Frontiers in Cellular and …, 2022 - frontiersin.org
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, and malaria,
caused by parasites from the Plasmodium genus, are two of the major causes of death due …
caused by parasites from the Plasmodium genus, are two of the major causes of death due …
Targeting Mycobacterium tuberculosis iron-scavenging tools: A recent update on siderophores inhibitors
G Kumar, PA Adhikrao - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
Among the various bacterial infections, tuberculosis (TB) remains a life-threatening
infectious disease responsible as the most significant cause of mortality and morbidity …
infectious disease responsible as the most significant cause of mortality and morbidity …
Recent advances in the development of DprE1 inhibitors using AI/CADD approaches
K Chen, R Xu, X Hu, D Li, T Hou, Y Kang - Drug Discovery Today, 2024 - Elsevier
Tuberculosis (TB) is a global lethal disease caused by Mycobacterium tuberculosis (Mtb).
The flavoenzyme decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1) plays a crucial part …
The flavoenzyme decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1) plays a crucial part …
Structural analysis of the housecleaning nucleoside triphosphate pyrophosphohydrolase MazG from Mycobacterium tuberculosis
S Wang, B Gao, A Chen, Z Zhang, S Wang… - Frontiers in …, 2023 - frontiersin.org
The housecleaning enzyme of Mycobacterium tuberculosis (Mtb), MazG, is a nucleoside
triphosphate pyrophosphohydrolase (NTP-PPase) and can hydrolyze all canonical or non …
triphosphate pyrophosphohydrolase (NTP-PPase) and can hydrolyze all canonical or non …
[HTML][HTML] Characteristics of alveolar macrophages in bronchioalveolar lavage fluids from active tuberculosis patients identified by single-cell RNA sequencing
Q Chen, C Hu, W Lu, T Hang, Y Shao… - Journal of Biomedical …, 2022 - ncbi.nlm.nih.gov
Tuberculosis (TB), is an infectious disease caused by Mycobacterium tuberculosis (M.
tuberculosis), and presents with high morbidity and mortality. Alveolar macrophages play an …
tuberculosis), and presents with high morbidity and mortality. Alveolar macrophages play an …
Machine learning prediction of mycobacterial cell wall permeability of drugs and drug-like compounds
EV Radchenko, GV Antonyan, SK Ignatov, VA Palyulin - Molecules, 2023 - mdpi.com
The cell wall of Mycobacterium tuberculosis and related organisms has a very complex and
unusual organization that makes it much less permeable to nutrients and antibiotics, leading …
unusual organization that makes it much less permeable to nutrients and antibiotics, leading …