Nicotine is a highly addictive drug found in tobacco that drives its continued use despite the
harmful consequences. The initiation of nicotine abuse involves the mesolimbic dopamine …

Tobacco smoking results in more than five million deaths each year and accounts for∼ 90%
of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco smoke …

Consistent but indirect evidence has implicated genetic factors in smoking behavior,. We
report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and …

Recently, genetic association findings for nicotine dependence, smoking behavior, and
smoking-related diseases converged to implicate the chromosome 15q25. 1 region, which …

An aversive abstinence syndrome manifests 4–24 h following cessation of chronic use of
nicotine-containing products. Symptoms peak on approximately the 3rd day and taper off …

Heavy-tailed high-dimensional data are commonly encountered in various scientific fields
and pose great challenges to modern statistical analysis. A natural procedure to address this …

Genetic association studies have shown the importance of variants in the CHRNA5-
CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit gene cluster on chromosome …

Tobacco smoking results in more than 5 million deaths each year and accounts for almost
90% of all deaths from lung cancer. Nicotine, the major reinforcing component of tobacco …

Genomic studies have identified a D398N variation in the α5 subunit of nicotinic
acetylcholine receptors (AChRs) that increases risk of nicotine dependence and lung …

DNA methylation is an epigenetic modification that is highly disrupted in response to
cigarette smoke and involved in a wide spectrum of malignant and nonmalignant diseases …