CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?

CS Walker, DL Hay - British Journal of Pharmacology, 2013 - Wiley Online Library
The neuropeptide calcitonin gene‐related peptide (CGRP) is reported to play an important
role in migraine. It is expressed throughout the trigeminovascular system. Antagonists …

The effects of CGRP in vascular tissue-classical vasodilation, shadowed effects and systemic dilemmas

I Sohn, M Sheykhzade, L Edvinsson, A Sams - European Journal of …, 2020 - Elsevier
Vascular tissue consists of endothelial cells, vasoactive smooth muscle cells and
perivascular nerves. The perivascular sensory neuropeptide CGRP has demonstrated …

[HTML][HTML] Heterogeneous vasomotor responses in segments from Göttingen Minipigs coronary, cerebral, and mesenteric artery: A comparative study

A Sams, KA Haanes, A Holm, S Kazantzi… - Vascular …, 2023 - Elsevier
Göttingen Minipigs (GM) are used as an important preclinical model for cardiovascular
safety pharmacology and for evaluation of cardiovascular drug targets. To improve the …

Investigation of CGRP receptors and peptide pharmacology in human coronary arteries. Characterization with a nonpeptide antagonist

P Hasbak, OS Opgaard, K Eskesen, S Schifter… - … of Pharmacology and …, 2003 - ASPET
Calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and amylin are structurally
related peptides mediating vasorelaxation in the coronary circulation possibly via CGRP …

Binding and functional pharmacological characteristics of gepant-type antagonists in rat brain and mesenteric arteries

M Sheykhzade, N Amandi, MV Pla… - Vascular …, 2017 - Elsevier
Aim The neuropeptide calcitonin gene-related peptide (CGRP) is found in afferent sensory
nerve fibers innervating the resistance arteries and plays a pivotal role in a number of …

[HTML][HTML] Calcitonin gene-related peptide: Understanding its role

S Ghatta, D Nimmagadda - Indian journal of pharmacology, 2004 - journals.lww.com
Calcitonin gene-related peptide (CGRP), a 37 amino acid neuropeptide, identified in
multiple species, has widespread distribution and expression. CGRP acts through G protein …

On the innervation of the donkey testis

KH Wrobel, MNK Moustafa - Annals of Anatomy-Anatomischer Anzeiger, 2000 - Elsevier
The innervation pattern of the adult donkey testis was investigated by immunohistochemistry
and acetylcholinesterase histochemistry. Autonomous nerves reach the testis by three …

Receptors mediating CGRP‐induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by hα CGRP8–37

FM Wisskirchen, DW Gray… - British journal of …, 1999 - Wiley Online Library
Receptors mediating CGRP‐induced vasorelaxation were investigated in rat thoracic aorta
and porcine left anterior descending (LAD) coronary artery and anterior interventricular …

The effect of long‐term streptozotocin‐induced diabetes on contractile and relaxation responses of coronary arteries: selective attenuation of CGRP‐induced …

M Sheykhzade, GT Dalsgaard… - British journal of …, 2000 - Wiley Online Library
This study investigates the effect of partially metabolic controlled long‐term (34 weeks)
streptozotocin (STZ)‐induced diabetes on relaxation and contractile responses of isolated …

Mechanism of CGRP‐induced relaxation in rat intramural coronary arteries

M Sheykhzade, NC Berg Nyborg - British journal of …, 2001 - Wiley Online Library
This study investigates the mechanism of CGRP‐induced relaxation in intramural coronary
arteries by determining the effect of CGRP on cytosolic Ca2+ concentration ([Ca2+] i) using …