Gene methylation-related enzymes (GMREs) are disfunction and aberrantly expressed in a
variety of cancers, such as lung, gastric, and pancreatic cancers and have important …

RNA demethylases play a crucial role in gene expression regulation by controlling RNA
methylation levels, and their abnormal expressions are associated with many human …

Ten-eleven translocation enzymes (TETs) are Fe (II)/2-oxoglutarate (2OG) oxygenases that
catalyze the sequential oxidation of 5-methylcytosine to 5-hydroxymethylcytosine, 5 …

In addition to the four canonical nucleosides dA, dG, dC and T, genomic DNA contains the
additional base 5‐methyldeoxycytidine (mdC). The presence of this methylated cytidine …

Abstract Ten-Eleven Translocation (TET) enzymes are Fe (II)/2OG-dependent oxygenases
that play important roles in epigenetic regulation, but selective inhibition of the TETs is an …

In brief Maternal obesity can impair metabolism in the embryo and the resulting offspring.
This study shows that metabolic disruptions through α-ketoglutarate may link altered …

N6-methyladenosine (m6A) demethylase is essential for enzymatically removing methyl
groups from m6A modifications and is significantly implicated in the pathogenesis and …

Abstract Fe (II)-and 2-oxoglutarate (2OG)-dependent dioxygenases use 2OG and O2
cofactors to catalyse substrate oxidation and yield oxidised product, succinate, and CO2 …

Conditional remodeling of enzyme catalysis is a formidable challenge in protein
engineering. Herein, we have undertaken a unique active site engineering tactic to …

Ten-eleven translocation (TET) family proteins play key roles in multiple cellular processes
by mediating the oxidation of 5-methylcytosine to directly participate in DNA demethylation …