Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement

R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …

Antimicrobial peptides as therapeutic agents: Opportunities and challenges

M Mahlapuu, C Björn, J Ekblom - Critical reviews in biotechnology, 2020 - Taylor & Francis
The rapid development of microbial resistance to conventional antibiotics has accelerated
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …

Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability

Z Lai, X Yuan, H Chen, Y Zhu, N Dong, A Shan - Biotechnology Advances, 2022 - Elsevier
Due to the alarming developing rate of multidrug-resistant bacterial pathogens, the
development and modification of antimicrobial peptides (AMPs) are unprecedentedly active …

Antimicrobial peptides towards clinical application: Delivery and formulation

C Wang, T Hong, P Cui, J Wang, J Xia - Advanced drug delivery reviews, 2021 - Elsevier
Antimicrobial peptides hold promise to supplement small molecules antibiotics and combat
the multidrug resistant microbes. There are however technical hurdles towards the clinical …

Interdisciplinary‐inspired smart antibacterial materials and their biomedical applications

Y Wu, P Liu, B Mehrjou, PK Chu - Advanced Materials, 2024 - Wiley Online Library
The discovery of antibiotics has saved millions of lives, but the emergence of antibiotic‐
resistant bacteria has become another problem in modern medicine. To avoid or reduce the …

Microencapsulation as a noble technique for the application of bioactive compounds in the food industry: A comprehensive review

N Mehta, P Kumar, AK Verma, P Umaraw, Y Kumar… - Applied Sciences, 2022 - mdpi.com
The use of natural food ingredients has been increased in recent years due to the negative
health implications of synthetic ingredients. Natural bioactive compounds are important for …

[HTML][HTML] Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era

L Lin, J Chi, Y Yan, R Luo, X Feng, Y Zheng… - … Pharmaceutica Sinica B, 2021 - Elsevier
Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or
anticarcinogens that present a general killing mechanism through the physical disruption of …

Current advances in lipid and polymeric antimicrobial peptide delivery systems and coatings for the prevention and treatment of bacterial infections

ME van Gent, M Ali, PH Nibbering, SN Kłodzińska - Pharmaceutics, 2021 - mdpi.com
Bacterial infections constitute a threat to public health as antibiotics are becoming less
effective due to the emergence of antimicrobial resistant strains and biofilm and persister …

Microstructures of encapsulates and their relations with encapsulation efficiency and controlled release of bioactive constituents: A review

P Yun, S Devahastin… - Comprehensive Reviews in …, 2021 - Wiley Online Library
Vitamins, peptides, essential oils, and probiotics are examples of health beneficial
constituents, which are nevertheless heat‐sensitive and possess poor chemical stability …

Incorporation of antibiotics into solid lipid nanoparticles: a promising approach to reduce antibiotic resistance emergence

L Arana, L Gallego, I Alkorta - Nanomaterials, 2021 - mdpi.com
Antimicrobial resistance is one of the biggest threats to global health as current antibiotics
are becoming useless against resistant infectious pathogens. Consequently, new …