Human dendritic cells: their heterogeneity and clinical application potential in cancer immunotherapy

TA Patente, MP Pinho, AA Oliveira… - Frontiers in …, 2019 - frontiersin.org
Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve
T cell activation and effector differentiation. They are, likewise, involved in the induction and …

Vaccine delivery systems toward lymph nodes

Y Ding, Z Li, A Jaklenec, Q Hu - Advanced drug delivery reviews, 2021 - Elsevier
Strategies of improving vaccine targeting ability toward lymph nodes have been attracting
considerable interest in recent years, though there are remaining delivery barriers based on …

Dendritic cell-derived exosomes may be a tool for cancer immunotherapy by converting tumor cells into immunogenic targets

GG Romagnoli, BB Zelante, PA Toniolo… - Frontiers in …, 2015 - frontiersin.org
Dendritic cells (DCs) have been attracting attention in cancer immunotherapy because of
their role in inducing and modulating effective immune responses. Besides the direct contact …

Trial watch: Dendritic cell-based interventions for cancer therapy

L Galluzzi, L Senovilla, E Vacchelli, A Eggermont… - …, 2012 - Taylor & Francis
Dendritic cells (DCs) occupy a central position in the immune system, orchestrating a wide
repertoire of responses that span from the development of self-tolerance to the elicitation of …

Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma

DE Avigan, B Vasir, DJ George, WK Oh… - Journal of …, 2007 - journals.lww.com
In the present study, we assessed the feasibility, toxicity, immunologic response, and clinical
efficacy of vaccination with allogeneic dendritic cell (DC)/tumor fusions in patients with …

Adjuvant vaccination with allogenic dendritic cells significantly prolongs overall survival in high-grade gliomas: Results of a phase II trial

G Lepski, PC Bergami-Santos, MP Pinho… - Cancers, 2023 - mdpi.com
Simple Summary Among all intracranial tumors, 31.5% are malignant, and among those,
glioblastomas account for 47%. Recently, our group reported the case of a patient with …

Monocyte-derived dendritic cells from breast cancer patients are biased to induce CD4+CD25+Foxp3+ regulatory T cells

RN Ramos, LS Chin, APSA Dos Santos… - Journal of leukocyte …, 2012 - academic.oup.com
Immune deviation induced by breast cancer may have a role in current failures of dendritic
cell-based immunotherapy. DCs orchestrate immune responses contributing to the pattern of …

Vaccine therapy in patients with renal cell carcinoma

H Van Poppel, S Joniau, SW Van Gool - European Urology, 2009 - Elsevier
CONTEXT: Renal cell carcinoma (RCC) is one of the most immunoresponsive cancers in
humans. Although immunotherapy is currently much less used than in the past, it remains an …

[HTML][HTML] Pattern response of dendritic cells in the tumor microenvironment and breast cancer

A da Cunha, MA Michelin, EFC Murta - World journal of clinical …, 2014 - ncbi.nlm.nih.gov
Breast cancer (BC) is the most common malignant neoplasm and the cause of death by
cancer among women worldwide. Its development, including malignancy grade and patient …

Immunotherapy for renal cell carcinoma

M Itsumi, K Tatsugami - Journal of Immunology Research, 2010 - Wiley Online Library
Immunotherapy plays a significant role in the management of renal cell carcinoma (RCC)
patients with metastatic disease because RCC is highly resistant to both chemotherapy and …