Organoid models have been used to address important questions in developmental and
cancer biology, tissue repair, advanced modelling of disease and therapies, among other …

Obesity represents a major public health problem with a prevalence increasing at an
alarming rate worldwide. Continuous intensive efforts to elucidate the complex …

Human mutations in neuropeptide Y (NPY) have been linked to high body mass index but
not altered dietary patterns. Here we uncover the mechanism by which NPY in sympathetic …

Through the past decade of research, the pathogenic mechanisms underlying metabolic
syndrome have been suggested to involve not only the peripheral tissues, but also central …

Carbapenem-resistant Klebsiella pneumoniae (CRKP) causes Gram-negative lung
infections and fatal pneumonic sepsis for which limited therapeutic options are available …

The central nervous system regulates activity of peripheral organs through interoception. In
our previous study, we have demonstrated that PGE2/EP4 skeleton interception regulate …

Adipose tissue can be divided anatomically, histologically, and functionally into two major
entities white and brown adipose tissues (WAT and BAT, respectively). WAT is the primary …

Mechanisms underlying long-term sustained weight loss and glycemic normalization after
obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 …

Chronic stress fuels the consumption of palatable food and can enhance obesity
development. While stress-and feeding-controlling pathways have been identified, how …

Aim To examine whether sequential administration of (d‐Arg35)‐sea lamprey peptide
tyrosine tyrosine (1–36)(SL‐PYY) and the glucagon‐like peptide‐1 (GLP‐1) mimetic …