A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Background The inflammation and oxidative stress (OS) have been considered crucial
components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger …

Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many
neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic …

Frailty and depression were linked in observational studies, but the causality remains
ambiguous. We intended to explore it using Mendelian randomization (MR). We obtained …

Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Highlights•The Reactive Oxygen Species have an utmost importance in progression of
Depression.•Depression is associated with lowered concentration of anti-oxidants in …

With depression being the psychiatric disorder incurring the largest societal costs in
developed countries, there is a need to gather evidence on the role of nutrition in …

Depression is one of the most debilitating psychiatric disorders affecting people of all ages
worldwide. Despite significant heterogeneity between studies, increased inflammation and …