Second generation androgen receptor antagonists and challenges in prostate cancer treatment

Y Chen, Q Zhou, W Hankey, X Fang, F Yuan - Cell Death & Disease, 2022 - nature.com
Prostate cancer is a hormone-dependent malignancy, whose onset and progression are
closely related to the activity of the androgen receptor (AR) signaling pathway. Due to this …

Androgen receptor pathway inhibitors, prostate cancer, and older adults: a global Young International Society of Geriatric Oncology drug review

N Mir, O Burke, S Yates… - Therapeutic …, 2023 - journals.sagepub.com
Prostate cancer is a disease of older adults that has undergone a significant therapeutic
paradigm shift in the last decade with the emergence of novel androgen receptor pathway …

Survival of veterans treated with enzalutamide and abiraterone for metastatic castrate resistant prostate cancer based on comorbid diseases

MW Schoen, KR Carson, SA Eisen… - Prostate Cancer and …, 2023 - nature.com
Background Comorbid diseases influence patient outcomes, yet little is known about how
comorbidities interact with treatments for metastatic castrate-resistant prostate cancer …

Hospitalizations among veterans treated for metastatic prostate cancer with abiraterone or enzalutamide

F Riekhof, Y Yan, CL Bennett, KM Sanfilippo… - Clinical Genitourinary …, 2024 - Elsevier
Background Abiraterone and enzalutamide are second generation androgen receptor
pathway inhibitors (ARPIs) used to treat advanced or metastatic prostate cancer. Without …

Long‐term use and risk of major adverse cardiac events: Comparing enzalutamide and abiraterone in chemotherapy‐naïve patients with metastatic castration …

HK Chen, PJ Su, YL Wang, KC Chang… - … Journal of Cancer, 2023 - Wiley Online Library
This is a retrospective cohort study by analyzing a multi‐institutional electronic medical
records database in Taiwan to compare long‐term effectiveness and risk of major adverse …

A multidisciplinary consensus statement on the optimal pharmacological treatment for metastatic hormone-sensitive prostate cancer

A Borque-Fernando, MA Calleja-Hernández… - Actas Urológicas …, 2023 - Elsevier
Androgen deprivation therapy (ADT) is the mainstay treatment for metastatic hormone-
sensitive prostate cancer (mHSPC). The addition of docetaxel or new hormone therapies …

Cardiovascular Adverse Events Associated With New-Generation Androgen Receptor Pathway Inhibitors (ARPI) for Prostate Cancer: A Disproportionality Analysis …

Y Liu, H Zhang, Y Jiang, Z Wen, E Bao, J Huang… - Clinical Genitourinary …, 2023 - Elsevier
Background The potential cardiovascular adverse events associated with new-generation
androgen receptor pathway inhibitors (ARPI) in the treatment of prostate cancer remain …

Consenso multidisciplinar sobre idoneidad farmacológica en cáncer de próstata hormono-sensible metastásico

A Borque-Fernando, MA Calleja-Hernández… - Actas Urológicas …, 2023 - Elsevier
La terapia de privación androgénica (TPA) es el pilar del tratamiento del cáncer de próstata
hormono-sensible metastásico (CPHSm). La adición de docetaxel o de nuevas terapias …

Major adverse cardiovascular events of enzalutamide versus abiraterone in prostate cancer: a retrospective cohort study

YHA Lee, JMH Hui, CH Leung, CTW Tsang… - Prostate cancer and …, 2023 - nature.com
Background While the cardiovascular risks of androgen receptor pathway inhibitors have
been studied, they were seldom compared directly. This study compares the risks of major …

Addressing the risk and management of cardiometabolic complications in prostate cancer patients on androgen deprivation therapy and androgen receptor axis …

D Poon, GM Tan, K Chan, MTY Chan, TW Chan… - Frontiers in …, 2024 - frontiersin.org
Background Androgen deprivation therapy (ADT) is the foundational treatment for metastatic
prostate cancer (PCa). Androgen receptor (AR) axis-targeted therapies are a new standard …