Purpose: The goals of this study were to survey and summarize the advances in imaging
that have potential applications in radiation oncology, and to explore the concept of …

The Ras gene product is a monomeric membrane-localized G protein of 21 kd that functions
as a molecular switch linking receptor and nonreceptor tyrosine kinase activation to …

Ras proteins are guanine nucleotide–binding proteins that play pivotal roles in the control of
normal and transformed cell growth and are among the most intensively studied proteins of …

The insulin-like growth factor-I receptor (IGF-IR) plays a critical role in cell growth regulation
and transformation. The radiosensitivity of NIH 3T3 fibroblasts overexpressing either wild …

Prenylation of proteins with polyisoprenoids is a functionally important post-translational
modification. Prenylation has been well characterized in mammalian cells1, 2 and has been …

Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th
Edition of this respected reference synthesizes all of the latest oncology knowledge in one …

In tumor cells with mutations in epidermal growth factor receptor (SQ20B), H-Ras (T24), or K-
Ras (MIAPACA2 and A549), the inhibition of Akt phosphorylation increases radiation …

Background and purpose: Experimental studies have implicated the normal or 'wild type'p53
protein (ie WTp53) in the cellular response to ionizing radiation and other DNA damaging …

Irradiation of normal eukaryotic cells results in delayed progression through the G1, S, and
G2 phases of the cell cycle. The G1 arrest is regulated by the p53 tumor suppressor gene …

This handbook presents the most current information on the effects of ionizing radiation on
mammalian cells, with emphasis on human tissues. The dose-effect relationship is …