CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers
ZM Ramdzan, A Nepveu - Nature Reviews Cancer, 2014 - nature.com
Abstract CUT-like homeobox 1 (CUX1) is a homeobox gene that is implicated in both tumour
suppression and progression. The accumulated evidence supports a model of …
suppression and progression. The accumulated evidence supports a model of …
The multiple roles of CUX1: insights from mouse models and cell-based assays
L Sansregret, A Nepveu - Gene, 2008 - Elsevier
Cux (Cut homeobox) genes are present in all metazoans. Early reports described many
phenotypes caused by cut mutations in Drosophila melanogaster. In vertebrates, CUX1 was …
phenotypes caused by cut mutations in Drosophila melanogaster. In vertebrates, CUX1 was …
[PDF][PDF] Liver‐enriched transcription factors regulate microRNA‐122 that targets CUTL1 during liver development
Abstract MicroRNA‐122 (miR‐122) is a liver‐specific microRNA whose expression is
specifically turned on in the mouse liver during embryogenesis, thus it is expected to be …
specifically turned on in the mouse liver during embryogenesis, thus it is expected to be …
MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma
K Kojima, A Takata, C Vadnais, M Otsuka… - Nature …, 2011 - nature.com
Abstract α-fetoprotein (AFP) is not only a widely used biomarker in hepatocellular carcinoma
(HCC) surveillance, but is also clinically recognized as linked with aggressive tumour …
(HCC) surveillance, but is also clinically recognized as linked with aggressive tumour …
CUX1: target of Akt signalling and mediator of resistance to apoptosis in pancreatic cancer
S Ripka, A Neesse, J Riedel, E Bug, A Aigner… - Gut, 2010 - gut.bmj.com
Background and aims The transcription factor CUX1 is known as a regulator of cell
differentiation and cell cycle progression. Previously, CUX1 was identified as a modulator of …
differentiation and cell cycle progression. Previously, CUX1 was identified as a modulator of …
CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage
C Vadnais, S Davoudi, M Afshin, R Harada… - Nucleic acids …, 2012 - academic.oup.com
The p110 Cut homeobox 1 (CUX1) transcription factor regulates genes involved in DNA
replication and chromosome segregation. Using a genome-wide-approach, we now …
replication and chromosome segregation. Using a genome-wide-approach, we now …
CUX1 transcription factors: from biochemical activities and cell-based assays to mouse models and human diseases
ChIP-chip and expression analyses indicated that CUX1 transcription factors regulate a
large number of genes and microRNAs involved in multiple cellular processes. Indeed, in …
large number of genes and microRNAs involved in multiple cellular processes. Indeed, in …
Algorithm for cellular reprogramming
S Ronquist, G Patterson, LA Muir… - Proceedings of the …, 2017 - National Acad Sciences
The day we understand the time evolution of subcellular events at a level of detail
comparable to physical systems governed by Newton's laws of motion seems far away. Even …
comparable to physical systems governed by Newton's laws of motion seems far away. Even …
CUX1, a controversial player in tumor development
N Liu, Q Sun, L Wan, X Wang, Y Feng, J Luo… - Frontiers in …, 2020 - frontiersin.org
CUX1 belongs to the homeodomain transcription factor family and is evolutionarily and
functionally conserved from Drosophila to humans. In addition to the involvement in various …
functionally conserved from Drosophila to humans. In addition to the involvement in various …
Cut homeodomain transcription factor is a novel regulator of growth and morphogenesis of cortex glia niche around neural cells
V Yadav, R Mishra, P Das, R Arya - Genetics, 2024 - academic.oup.com
Cortex glia in Drosophila central nervous system form a niche around neural cells for
necessary signals to establish cross talk with their surroundings. These cells grow and …
necessary signals to establish cross talk with their surroundings. These cells grow and …