Macroautophagy (herein referred to as autophagy) is an evolutionary ancient mechanism
that culminates with the lysosomal degradation of superfluous or potentially dangerous …

Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Autophagy influences cell survival through maintenance of cell bioenergetics and clearance
of protein aggregates and damaged organelles. Several lines of evidence indicate that …

Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …

Autophagy is well equipped functionally to isolate microbial pathogens in autophagosomes
and to carry out their clearance by dismemberment in the course of catabolic processes in …

Abstract LC3-associated phagocytosis (LAP) is a process wherein elements of autophagy
conjugate LC3 to phagosomal membranes. We characterize the molecular requirements for …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

Autophagy has broad functions in immunity, ranging from cell-autonomous defence to
coordination of complex multicellular immune responses. The successful resolution of …

The cellular degradative pathway of autophagy has a fundamental role in immunity. Here,
we review the function of autophagy and autophagy proteins in inflammation. We discuss …