Unresolved inflammation is a key mediator of advanced heart failure. Especially, damage,
pathogen, and lifestyle-associated molecular patterns are the major factors in initiating …

Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Abstract Maresin-2 (MaR2) is a specialized pro-resolution lipid mediator (SPM) that reduces
neutrophil recruitment in zymosan peritonitis. Here, we investigated the analgesic effect of …

Neuropathic pain (NP) is a chronic condition that results from a lesion or disease of the
nervous system, greatly impacting patients' quality of life. Current pharmacotherapy options …

Chronic pain (CP) is a severe clinical entity with devastating physical and emotional
consequences for patients, which can occur in a myriad of diseases. Often, conventional …

Chronic pain is a refractory health disease worldwide causing an enormous economic
burden on individuals and society. Accumulating evidence suggests that inflammation in the …

During an infection, inflammation mobilizes immune cells to eliminate the pathogen and
protect the host. However, inflammation can be detrimental when exacerbated and/or …

Inflammation is a fundamental physiological response orchestrated by innate immune cells
to restore tissue homeostasis. Specialized pro-resolving mediators (SPMs) are involved in …

Natural or synthetic ligands for peroxisome proliferator-activated receptor gamma (PPAR-γ)
represent an interesting tool for pharmacological interventions to treat inflammatory …

Background Sleep disturbances, as manifested in insomnia symptoms of difficulties falling
asleep or frequent nighttime awakenings, are a strong risk factor for a diverse range of …