Last year brought a significant advance in asthma management, unyielding to the pressure
of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell …

Asthma is a disease of reversible airflow obstruction characterised clinically by wheezing,
shortness of breath, and coughing. Increases in airway type 2 cytokine activity, including …

Rationale: Cross-sectional studies suggest an exacerbation-prone asthma (EPA) phenotype
and the utility of blood eosinophils and plasma IL-6 as predictive biomarkers. Objectives: To …

Monoclonal antibodies targeting IgE or the type-2 cytokines interleukin (IL)-4, IL-5 and IL-13
are proving highly effective in reducing exacerbations and symptoms in people with severe …

Although the term “asthma” has been applied to all patients with airway lability and variable
chest symptoms for centuries, phenotypes of asthma with distinct clinical and molecular …

Although eosinophilic inflammation is characteristic of asthma pathogenesis, neutrophilic
inflammation is also marked, and eosinophils and neutrophils can coexist in some cases …

Background Whether blood eosinophil counts and exhaled nitric oxide (FeNO) are
associated with important outcomes in mild asthma is unclear. In this prespecified subgroup …

This document incorporates recommendations from the 2021 Canadian Thoracic Society
(CTS) Guideline–A Focused Update on the Management of Very Mild and Mild Asthma 1 …

Currently, and based on the development of relevant biologic therapies, T2-high is the most
well-defined endotype of asthma. Although much progress has been made in elucidating T2 …

Background Asthma affects 350 million people worldwide including 45% to 70% with mild
disease. Treatment is mainly with inhalers containing beta₂‐agonists, typically taken as …