Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such
as palatable food, sexual activity and social interaction) and modulates the rewarding effects …

In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …

The development of alcohol use disorder (AUD) involves binge or heavy drinking to high
levels of intoxication that leads to compulsive intake, the loss of control in limiting intake, and …

The psychoactive constituent in cannabis, Δ9-tetrahydrocannabinol (THC), was isolated in
the mid-1960s, but the cannabinoid receptors, CB1 and CB2, and the major endogenous …

PURPOSE The purpose of this review is to discuss the literature regarding the concurrent
use (co-use) of alcohol and cannabis and competing hypotheses as to whether cannabis …

Cannabis has long been known to produce cognitive and emotional effects. Research has
shown that cannabinoid drugs produce these effects by driving the brain's endogenous …

The endocannabinoid system consists of the cannabinoid (CB) receptors, CB1 and CB2, the
endogenous ligands anandamide (AEA, arachidonoylethanolamide) and 2 …

Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors. These
receptors are also the primary molecular target responsible for the pharmacological effects …

The endogenous cannabinoid system is an important regulatory system involved in
physiological homeostasis. Endocannabinoid signaling is known to modulate neural …

Dysregulation in signaling of the endocannabinoid 2-arachidonoylglycerol (2-AG) is
implicated in hyperresponsiveness to stress. We hypothesized that blockade of …