Astrocytes, through their close associations with synapses, can monitor and alter synaptic
function, thus actively controlling synaptic transmission in the adult brain. Besides their …

Alzheimer's disease (AD) is a debilitating, chronic neurodegenerative disease. Genetic
studies involving genome-wide association studies (GWAS) and meta-analysis have …

Astrocytes become reactive following various brain insults; however, the functions of reactive
astrocytes are poorly understood. Here, we show that reactive astrocytes function as …

To achieve its precise neural connectivity, the developing mammalian nervous system
undergoes extensive activity-dependent synapse remodelling. Recently, microglial cells …

Astrocytes are now emerging as key participants in many aspects of brain development,
function and disease. In particular, new evidence shows that astrocytes powerfully control …

Clearance of apoptotic cells is the final stage of programmed cell death. Uncleared corpses
can become secondarily necrotic, promoting inflammation and autoimmunity. Remarkably …

Everyday we turnover billions of cells. The quick, efficient, and immunologically silent
disposal of the dying cells requires a coordinated orchestration of multiple steps, through …

In the human body, billions of cells die by apoptosis every day. The subsequent clearance of
apoptotic cells by phagocytosis is normally efficient enough to prevent secondary necrosis …

The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a
large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of …

Phagosome maturation is the process by which internalized particles (such as bacteria and
apoptotic cells) are trafficked into a series of increasingly acidified membrane-bound …