Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Glioblastoma is the most aggressive and the most common primary malignant brain tumor in
adults. Risk factors for glioblastoma are widely elusive and the clinical course is generally …

The epidermal growth factor receptor (EGFR) is frequently mutated in human cancer,, and is
an important therapeutic target. EGFR inhibitors have been successful in lung cancer, where …

Glioblastoma (GBM) is one of the most aggressive and deadliest central nervous system
tumors, and the current standard treatment is surgery followed by radiotherapy with …

Simple Summary Glioblastoma is the most common brain cancer, and prognosis remains
dismal. Continued efforts to find better treatments have shown the promise of …

Natural killer (NK) cells are promising effector cells for adjuvant immunotherapy of cancer.
So far, several preclinical studies have shown the feasibility of gene-engineered NK cells …

Antibody-based therapy has revitalized the world of cancer therapeutics since rituximab was
first approved for the treatment of Non-Hodgkin's Lymphoma. Monoclonal antibodies against …

Glioblastoma is the most common and most aggressive primary brain malignancy. The
current initial standard of care consists of maximal safe surgical resection followed by radical …

Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about
half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR …