A comprehensive metabolic map for production of bio-based chemicals
Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …
increasingly important to address limited fossil resources, climate change and other …
Metabolic engineering in the host Yarrowia lipolytica
The nonconventional, oleaginous yeast, Yarrowia lipolytica is rapidly emerging as a
valuable host for the production of a variety of both lipid and nonlipid chemical products …
valuable host for the production of a variety of both lipid and nonlipid chemical products …
Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals
Harnessing lipogenic pathways and rewiring acyl-CoA and acyl-ACP (acyl carrier protein)
metabolism in Yarrowia lipolytica hold great potential for cost-efficient production of diesel …
metabolism in Yarrowia lipolytica hold great potential for cost-efficient production of diesel …
Metabolic engineering of Pseudomonas putida for increased polyhydroxyalkanoate production from lignin
D Salvachúa, T Rydzak, R Auwae… - Microbial …, 2020 - Wiley Online Library
Microbial conversion offers a promising strategy for overcoming the intrinsic heterogeneity of
the plant biopolymer, lignin. Soil microbes that natively harbour aromatic‐catabolic …
the plant biopolymer, lignin. Soil microbes that natively harbour aromatic‐catabolic …
Barriers and opportunities in bio-based production of hydrocarbons
Global climate change caused by the accumulation of greenhouse gases (GHGs) has
caused concerns regarding the continued reliance on fossil fuels as our primary energy …
caused concerns regarding the continued reliance on fossil fuels as our primary energy …
Machine learning-guided acyl-ACP reductase engineering for improved in vivo fatty alcohol production
JC Greenhalgh, SA Fahlberg, BF Pfleger… - Nature …, 2021 - nature.com
Alcohol-forming fatty acyl reductases (FARs) catalyze the reduction of thioesters to alcohols
and are key enzymes for microbial production of fatty alcohols. Many metabolic engineering …
and are key enzymes for microbial production of fatty alcohols. Many metabolic engineering …
Multidimensional engineering of Saccharomyces cerevisiae for efficient synthesis of medium-chain fatty acids
Medium-chain fatty acids (MCFAs; C6–C12) are valuable molecules used for biofuel and
oleochemical production; however, it is challenging to synthesize these fatty acids efficiently …
oleochemical production; however, it is challenging to synthesize these fatty acids efficiently …
Engineering oxidative stress defense pathways to build a robust lipid production platform in Yarrowia lipolytica
Microbially derived lipids have recently attracted renewed interests due to their broad
applications in production of green diesels, cosmetic additives, and oleochemicals …
applications in production of green diesels, cosmetic additives, and oleochemicals …
Oleaginous yeasts: promising platforms for the production of oleochemicals and biofuels
JL Adrio - Biotechnology and bioengineering, 2017 - Wiley Online Library
Oleaginous yeasts have a unique physiology that makes them the best suited hosts for the
production of lipids, oleochemicals, and diesel‐like fuels. Their high lipogenesis, capability …
production of lipids, oleochemicals, and diesel‐like fuels. Their high lipogenesis, capability …
The pentose phosphate pathway in yeasts–more than a poor cousin of glycolysis
LK Bertels, L Fernández Murillo, JJ Heinisch - Biomolecules, 2021 - mdpi.com
The pentose phosphate pathway (PPP) is a route that can work in parallel to glycolysis in
glucose degradation in most living cells. It has a unidirectional oxidative part with glucose-6 …
glucose degradation in most living cells. It has a unidirectional oxidative part with glucose-6 …