A comprehensive metabolic map for production of bio-based chemicals

SY Lee, HU Kim, TU Chae, JS Cho, JW Kim, JH Shin… - Nature …, 2019 - nature.com
Production of industrial chemicals using renewable biomass feedstock is becoming
increasingly important to address limited fossil resources, climate change and other …

Metabolic engineering in the host Yarrowia lipolytica

AM Abdel-Mawgoud, KA Markham, CM Palmer… - Metabolic …, 2018 - Elsevier
The nonconventional, oleaginous yeast, Yarrowia lipolytica is rapidly emerging as a
valuable host for the production of a variety of both lipid and nonlipid chemical products …

Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals

P Xu, K Qiao, WS Ahn… - Proceedings of the …, 2016 - National Acad Sciences
Harnessing lipogenic pathways and rewiring acyl-CoA and acyl-ACP (acyl carrier protein)
metabolism in Yarrowia lipolytica hold great potential for cost-efficient production of diesel …

Metabolic engineering of Pseudomonas putida for increased polyhydroxyalkanoate production from lignin

D Salvachúa, T Rydzak, R Auwae… - Microbial …, 2020 - Wiley Online Library
Microbial conversion offers a promising strategy for overcoming the intrinsic heterogeneity of
the plant biopolymer, lignin. Soil microbes that natively harbour aromatic‐catabolic …

Barriers and opportunities in bio-based production of hydrocarbons

YJ Zhou, EJ Kerkhoven, J Nielsen - Nature Energy, 2018 - nature.com
Global climate change caused by the accumulation of greenhouse gases (GHGs) has
caused concerns regarding the continued reliance on fossil fuels as our primary energy …

Machine learning-guided acyl-ACP reductase engineering for improved in vivo fatty alcohol production

JC Greenhalgh, SA Fahlberg, BF Pfleger… - Nature …, 2021 - nature.com
Alcohol-forming fatty acyl reductases (FARs) catalyze the reduction of thioesters to alcohols
and are key enzymes for microbial production of fatty alcohols. Many metabolic engineering …

Multidimensional engineering of Saccharomyces cerevisiae for efficient synthesis of medium-chain fatty acids

Z Zhu, Y Hu, PG Teixeira, R Pereira, Y Chen… - Nature Catalysis, 2020 - nature.com
Medium-chain fatty acids (MCFAs; C6–C12) are valuable molecules used for biofuel and
oleochemical production; however, it is challenging to synthesize these fatty acids efficiently …

Engineering oxidative stress defense pathways to build a robust lipid production platform in Yarrowia lipolytica

P Xu, K Qiao, G Stephanopoulos - Biotechnology and …, 2017 - Wiley Online Library
Microbially derived lipids have recently attracted renewed interests due to their broad
applications in production of green diesels, cosmetic additives, and oleochemicals …

Oleaginous yeasts: promising platforms for the production of oleochemicals and biofuels

JL Adrio - Biotechnology and bioengineering, 2017 - Wiley Online Library
Oleaginous yeasts have a unique physiology that makes them the best suited hosts for the
production of lipids, oleochemicals, and diesel‐like fuels. Their high lipogenesis, capability …

The pentose phosphate pathway in yeasts–more than a poor cousin of glycolysis

LK Bertels, L Fernández Murillo, JJ Heinisch - Biomolecules, 2021 - mdpi.com
The pentose phosphate pathway (PPP) is a route that can work in parallel to glycolysis in
glucose degradation in most living cells. It has a unidirectional oxidative part with glucose-6 …