Many methods for reducing the immunosuppressive requirements of allotransplantation
have been proposed based on a growing understanding of physiological and allospecific …

Monoclonal antibodies (mAbs) and fusion proteins directed towards cell surface targets
make an important contribution to the treatment of disease. The purpose of this review was …

Adeno-associated virus (AAV)–mediated gene transfer of factor IX (F. IX) to the liver results
in long-term expression of transgene in experimental animals, but only short-term …

Aims To understand wound healing after drug-eluting stents (DES) placement in humans,
we studied the histology of in-stent restenosis (ISR) tissue obtained by atherectomy from …

CD154-specific antibody therapy prevents allograft rejection in many experimental
transplant models. However, initial clinical transplant trials with anti-CD154 have been …

Background. Composite tissue allotransplantation (CTA) has been recently introduced as a
potential treatment for tissue loss secondary to burns, injuries, or resections. However, the …

Small bowel transplantation has become an established procedure for treatment of
irreversible intestinal failure. In this procedure, primary ischemia and reperfusion is …

Objectives: The aim of this study was to compare efficacy of low-and high-dose sirolimus
release (25, 40, or 100 μg) from hydroxyapatite (HAp) with Cypher (Cordis, Johnson & …

Large animal models have long served as the proving grounds for advances in
transplantation, bridging the gap between inbred mouse experimentation and human …

Background: Various groups have reported prolonged diabetes reversal and graft function
after porcine islet transplantation into diabetic macaques using different experimental …