Crossing the bridge: large animal models in translational transplantation research
AD Kirk - Immunological reviews, 2003 - Wiley Online Library
Many methods for reducing the immunosuppressive requirements of allotransplantation
have been proposed based on a growing understanding of physiological and allospecific …
have been proposed based on a growing understanding of physiological and allospecific …
Concordance of preclinical and clinical pharmacology and toxicology of therapeutic monoclonal antibodies and fusion proteins: cell surface targets
PJ Bugelski, PL Martin - British Journal of Pharmacology, 2012 - Wiley Online Library
Monoclonal antibodies (mAbs) and fusion proteins directed towards cell surface targets
make an important contribution to the treatment of disease. The purpose of this review was …
make an important contribution to the treatment of disease. The purpose of this review was …
Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver
F Mingozzi, NC Hasbrouck… - Blood, The Journal …, 2007 - ashpublications.org
Adeno-associated virus (AAV)–mediated gene transfer of factor IX (F. IX) to the liver results
in long-term expression of transgene in experimental animals, but only short-term …
in long-term expression of transgene in experimental animals, but only short-term …
Drug-eluting stents show delayed healing: paclitaxel more pronounced than sirolimus
HMM van Beusekom, F Saia, JD Zindler… - European Heart …, 2007 - academic.oup.com
Aims To understand wound healing after drug-eluting stents (DES) placement in humans,
we studied the histology of in-stent restenosis (ISR) tissue obtained by atherectomy from …
we studied the histology of in-stent restenosis (ISR) tissue obtained by atherectomy from …
[HTML][HTML] IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates
CD154-specific antibody therapy prevents allograft rejection in many experimental
transplant models. However, initial clinical transplant trials with anti-CD154 have been …
transplant models. However, initial clinical transplant trials with anti-CD154 have been …
Composite tissue allotransplantation: development of a preclinical model in nonhuman primates
LC Cendales, H Xu, J Bacher, MA Eckhaus… - …, 2005 - journals.lww.com
Background. Composite tissue allotransplantation (CTA) has been recently introduced as a
potential treatment for tissue loss secondary to burns, injuries, or resections. However, the …
potential treatment for tissue loss secondary to burns, injuries, or resections. However, the …
The pig as a preclinical model for intestinal ischemia-reperfusion and transplantation studies
T Yandza, M Tauc, MC Saint-Paul, M Ouaissi… - journal of surgical …, 2012 - Elsevier
Small bowel transplantation has become an established procedure for treatment of
irreversible intestinal failure. In this procedure, primary ischemia and reperfusion is …
irreversible intestinal failure. In this procedure, primary ischemia and reperfusion is …
Lowering the dose of sirolimus, released from a nonpolymeric hydroxyapatite coated coronary stent, reduces signs of delayed healing
WJ van der Giessen, O Sorop, PW Serruys… - JACC: Cardiovascular …, 2009 - jacc.org
Objectives: The aim of this study was to compare efficacy of low-and high-dose sirolimus
release (25, 40, or 100 μg) from hydroxyapatite (HAp) with Cypher (Cordis, Johnson & …
release (25, 40, or 100 μg) from hydroxyapatite (HAp) with Cypher (Cordis, Johnson & …
Primate models in organ transplantation
DJ Anderson, AD Kirk - Cold Spring …, 2013 - perspectivesinmedicine.cshlp.org
Large animal models have long served as the proving grounds for advances in
transplantation, bridging the gap between inbred mouse experimentation and human …
transplantation, bridging the gap between inbred mouse experimentation and human …
The usefulness and limitations of the diabetic macaque model in evaluating long‐term porcine islet xenograft survival
ML Graham, HJ Schuurman - Xenotransplantation, 2013 - Wiley Online Library
Background: Various groups have reported prolonged diabetes reversal and graft function
after porcine islet transplantation into diabetic macaques using different experimental …
after porcine islet transplantation into diabetic macaques using different experimental …