Increasing concern over microplastics has recently brought increased attention to studies on
microplastic toxicity. Here, we conduct a systematic review on toxicity of microplastics that …

Drug toxicity evaluation is an essential process of drug development as it is reportedly
responsible for the attrition of approximately 30% of drug candidates. The rapid increase in …

Animals and animal models have been invaluable for our current understanding of human
and animal biology, including physiology, pharmacology, biochemistry, and disease …

Quaternary ammonium compounds are antimicrobial chemicals that provide significant
public health benefits by controlling bacteria and viruses that cause infections such as colds …

The growing concern on nanoplastics (< 1 μm) impact on marine life has stimulated a
significant amount of studies aiming to address ecotoxicity and disclose their mechanisms of …

Background Hazard identification, risk assessment, regulatory, and policy activity are usually
conducted on a chemical-by-chemical basis. Grouping chemicals into categories or classes …

An adverse outcome pathway (AOP) is a compact representation of the available
mechanistic information on observed adverse effects upon environmental exposure. Sharing …

A number of initiatives in Europe, North America and at the OECD over the last 20 years
have played a significant role in accelerating the use of alternatives to animals for regulatory …

Nanomaterial development is one of the most significant technological advances of the 21st
century, with considerable impact in several fields. However, nanomaterials can pose risks …

Introduction: The AOP-Wiki is the main platform for the development and storage of adverse
outcome pathways (AOPs). These AOPs describe mechanistic information about …