The intramembrane protease γ-secretase is a hetero-tetrameric protein complex with
presenilin as the catalytic subunit and cleaves its membrane protein substrates within their …

The Alzheimer's disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by
α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These …

The subventricular zone (SVZ) of the anterolateral ventricle and the subgranular zone (SGZ)
of the hippocampal dentate gyrus are the two main regions of the adult mammalian brain in …

Neurotrophins and their receptors modulate multiple signalling pathways to regulate
neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity …

It is anticipated that γ-secretase inhibitors (γ-Sec-I) that modulate Notch processing will alter
differentiation in tissues whose architecture is governed by Notch signaling. To explore this …

Abstract γ-Secretase—a protease that cleaves within the membrane—was first recognized
for its role in the production of amyloidogenic Aβ peptides, but was subsequently found to …

Axoplasmic proteins containing nuclear localization signals (NLS) signal retrogradely by an
unknown mechanism in injured nerve. Here we demonstrate that the importin/karyopherin α …

During neuronal development, neurotrophins are essential factors that promote survival,
differentiation and myelination of neurons. The trophic signals are relayed to the cells via …

Members of the metzincin family of metalloproteinases have long been considered merely
degradative enzymes for extracellular matrix molecules. Recently, however, there has been …

The nerve growth factor family of growth factors, collectively known as neurotrophins, are
evolutionarily ancient regulators with an enormous range of biological functions. Reflecting …