Assembly, structure, function and regulation of type III secretion systems

W Deng, NC Marshall, JL Rowland… - Nature Reviews …, 2017 - nature.com
Type III secretion systems (T3SSs) are protein transport nanomachines that are found in
Gram-negative bacterial pathogens and symbionts. Resembling molecular syringes, T3SSs …

Protein-injection machines in bacteria

JE Galán, G Waksman - Cell, 2018 - cell.com
Many bacteria have evolved specialized nanomachines with the remarkable ability to inject
multiple bacterially encoded effector proteins into eukaryotic or prokaryotic cells. Known as …

Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells

JE Galán, M Lara-Tejero, TC Marlovits… - Annual review of …, 2014 - annualreviews.org
One of the most exciting developments in the field of bacterial pathogenesis in recent years
is the discovery that many pathogens utilize complex nanomachines to deliver bacterially …

Protein export according to schedule: architecture, assembly, and regulation of type III secretion systems from plant-and animal-pathogenic bacteria

D Büttner - Microbiology and Molecular Biology Reviews, 2012 - Am Soc Microbiol
Flagellar and translocation-associated type III secretion (T3S) systems are present in most
Gram-negative plant-and animal-pathogenic bacteria and are often essential for bacterial …

The type III secretion injectisome

GR Cornelis - Nature Reviews Microbiology, 2006 - nature.com
The type III secretion injectisome is a complex nanomachine that allows bacteria to deliver
protein effectors across eukaryotic cellular membranes. In recent years, significant progress …

Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion

GN Schroeder, H Hilbi - Clinical microbiology reviews, 2008 - Am Soc Microbiol
Shigella spp. are gram-negative pathogenic bacteria that evolved from harmless
enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research …

Atomic model of the type III secretion system needle

A Loquet, NG Sgourakis, R Gupta, K Giller, D Riedel… - Nature, 2012 - nature.com
Pathogenic bacteria using a type III secretion system (T3SS), to manipulate host cells cause
many different infections including Shigella dysentery, typhoid fever, enterohaemorrhagic …

Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin

J Hu, LJ Worrall, C Hong, M Vuckovic… - Nature …, 2018 - nature.com
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine
essential for the virulence of many disease causing Gram-negative bacteria. At the core of …

A common evolutionary origin for tailed-bacteriophage functional modules and bacterial machineries

D Veesler, C Cambillau - Microbiology and Molecular Biology …, 2011 - Am Soc Microbiol
Bacteriophages belonging to the order Caudovirales possess a tail acting as a molecular
nanomachine used during infection to recognize the host cell wall, attach to it, pierce it, and …

Visualization of the type III secretion mediated Salmonella–host cell interface using cryo-electron tomography

D Park, M Lara-Tejero, MN Waxham, W Li, B Hu… - Elife, 2018 - elifesciences.org
Many important gram-negative bacterial pathogens use highly sophisticated type III protein
secretion systems (T3SSs) to establish complex host-pathogen interactions. Bacterial-host …