Recent milestones in the understanding of gastric acid secretion and treatment of acid-
peptic disorders include the (1) discovery of histamine H2-receptors and development of …

Obesity is one of the major challenges to human health worldwide; however, there are
currently no effective pharmacological interventions for obesity. Recent studies have …

The major active product of ghrelin gene is a 28-amino acid peptide acylated at the serine 3
position with an octanoyl group, called simply ghrelin. Ghrelin has a multiplicity of …

Ghrelin is 28‐amino‐acid peptide that was discovered from the rat and human stomach in
1999. Since the discovery of ghrelin, various functions of ghrelin, including growth hormone …

Numerous peptides released from endocrine cells in the intestinal mucosa were established
early on to be involved in the physiological regulation of food intake with a prominent role in …

Objective Obesity is a growing worldwide health problem affecting both adults and children.
Effective prevention and treatment modalities can be achieved by understanding the …

Obestatin and ghrelin are two peptides derived from the same prohormone. It is well
established that ghrelin is produced by endocrine cells in the gastric mucosa. However, the …

We continue to make progress in our understanding of the regulation of gastric acid
secretion in health and disease. A better understanding of the pathways and mechanisms …

The gastric X/A-like endocrine cell receives growing attention due to its peptide products
with ghrelin being the best characterized. This peptide hormone was identified a decade …

Obestatin, a novel 23 amino acid amidated peptide encoded by the same gene with ghrelin,
was initially reported to reduce food intake, body weight gain, gastric emptying and suppress …