Statistical and integrative system-level analysis of DNA methylation data
AE Teschendorff, CL Relton - Nature Reviews Genetics, 2018 - nature.com
Epigenetics plays a key role in cellular development and function. Alterations to the
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
epigenome are thought to capture and mediate the effects of genetic and environmental risk …
[HTML][HTML] Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals
RF Hillary, DL McCartney, HM Smith, E Bernabeu… - PLoS …, 2023 - journals.plos.org
Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …
[HTML][HTML] Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling
DNA methylation microarrays can be employed to interrogate cell-type composition in
complex tissues. Here, we expand reference-based deconvolution of blood DNA …
complex tissues. Here, we expand reference-based deconvolution of blood DNA …
Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi
The minfi package is widely used for analyzing Illumina DNA methylation array data. Here
we describe modifications to the minfi package required to support the …
we describe modifications to the minfi package required to support the …
[HTML][HTML] An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray
Genome-wide methylation arrays are powerful tools for assessing cell composition of
complex mixtures. We compare three approaches to select reference libraries for …
complex mixtures. We compare three approaches to select reference libraries for …
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
PJ Hop, RAJ Zwamborn, E Hannon… - Science translational …, 2022 - science.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …
heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) …
DNA methylation‐based biomarkers of aging were slowed down in a two‐year diet and physical activity intervention trial: The DAMA study
Several biomarkers of healthy aging have been proposed in recent years, including the
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …
epigenetic clocks, based on DNA methylation (DNAm) measures, which are getting …
EWAS Open Platform: integrated data, knowledge and toolkit for epigenome-wide association study
Abstract Epigenome-Wide Association Study (EWAS) has become a standard strategy to
discover DNA methylation variation of different phenotypes. Since 2018, we have developed …
discover DNA methylation variation of different phenotypes. Since 2018, we have developed …
[HTML][HTML] Gene set enrichment analysis for genome-wide DNA methylation data
DNA methylation is one of the most commonly studied epigenetic marks, due to its role in
disease and development. Illumina methylation arrays have been extensively used to …
disease and development. Illumina methylation arrays have been extensively used to …
Decoding the genetic and epigenetic basis of asthma
Asthma is a complex and heterogeneous chronic inflammatory disease of the airways.
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …
Alongside environmental factors, asthma susceptibility is strongly influenced by genetics …