IgA and FcαRI: pathological roles and therapeutic opportunities
A Breedveld, M Van Egmond - Frontiers in immunology, 2019 - frontiersin.org
Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …
The production of IgA exceeds the production of all other antibodies combined, supporting …
More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …
Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation
With the increased distribution of microplastics in the environment, the potential for harmful
effects on human health and ecosystems have become a global concern. Considering that …
effects on human health and ecosystems have become a global concern. Considering that …
Salivary defense proteins: their network and role in innate and acquired oral immunity
TK Fábián, P Hermann, A Beck, P Fejérdy… - International journal of …, 2012 - mdpi.com
There are numerous defense proteins present in the saliva. Although some of these
molecules are present in rather low concentrations, their effects are additive and/or …
molecules are present in rather low concentrations, their effects are additive and/or …
Fc‐receptors as regulators of immunity
F Nimmerjahn, JV Ravetch - Advances in immunology, 2007 - Elsevier
Receptors for immunoglobulins [Fc‐receptors (FcRs)] are widely expressed throughout the
immune system. By binding to the antibody Fc‐portion, they provide a link between the …
immune system. By binding to the antibody Fc‐portion, they provide a link between the …
The era of the immunoglobulin A Fc receptor Fcα RI; its function and potential as target in disease
E Aleyd, MH Heineke, M van Egmond - Immunological reviews, 2015 - Wiley Online Library
Immunoglobulin A (IgA) is the most prevalent antibody at mucosal sites, and has an
important role in defense by preventing invasion of pathogens. Traditionally, IgA has been …
important role in defense by preventing invasion of pathogens. Traditionally, IgA has been …
Role of secretory IgA in the mucosal sensing of commensal bacteria
A Mathias, B Pais, L Favre, J Benyacoub… - Gut microbes, 2014 - Taylor & Francis
While the gut epithelium represents the largest mucosal tissue, the mechanisms underlying
the interaction between intestinal bacteria and the host epithelium lead to multiple outcomes …
the interaction between intestinal bacteria and the host epithelium lead to multiple outcomes …
Assessment of monoclonal gammopathies by nephelometric measurement of individual immunoglobulin κ/λ ratios
AR Bradwell, SJ Harding, NJ Fourrier… - Clinical …, 2009 - academic.oup.com
Background: Currently, monoclonal immunoglobulins are identified and quantified from
bands on electrophoretic gels. As an alternative, clonality might be determined by …
bands on electrophoretic gels. As an alternative, clonality might be determined by …
Re-thinking the functions of IgA+ plasma cells
JL Gommerman, OL Rojas, JH Fritz - Gut microbes, 2014 - Taylor & Francis
The intestinal mucosa harbors the largest population of antibody (Ab)-secreting plasma cells
(PC) in the human body, producing daily several grams of immunoglobulin A (IgA). IgA has …
(PC) in the human body, producing daily several grams of immunoglobulin A (IgA). IgA has …
Involvement of Fc receptors in disorders of the central nervous system
Immunoglobulins are proteins with a highly variable antigen-binding domain and a constant
region (Fc domain) that binds to a cell surface receptor (FcR). Activation of FcRs in immune …
region (Fc domain) that binds to a cell surface receptor (FcR). Activation of FcRs in immune …