IgA and FcαRI: pathological roles and therapeutic opportunities

A Breedveld, M Van Egmond - Frontiers in immunology, 2019 - frontiersin.org
Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …

More than just a barrier: the immune functions of the airway epithelium in asthma pathogenesis

A Frey, LP Lunding, JC Ehlers, M Weckmann… - Frontiers in …, 2020 - frontiersin.org
Allergic bronchial asthma is a chronic disease of the airways that is characterized by
symptoms like respiratory distress, chest tightness, wheezing, productive cough, and acute …

Repeated-oral dose toxicity of polyethylene microplastics and the possible implications on reproduction and development of the next generation

EJ Park, JS Han, EJ Park, E Seong, GH Lee, DW Kim… - Toxicology letters, 2020 - Elsevier
With the increased distribution of microplastics in the environment, the potential for harmful
effects on human health and ecosystems have become a global concern. Considering that …

Salivary defense proteins: their network and role in innate and acquired oral immunity

TK Fábián, P Hermann, A Beck, P Fejérdy… - International journal of …, 2012 - mdpi.com
There are numerous defense proteins present in the saliva. Although some of these
molecules are present in rather low concentrations, their effects are additive and/or …

Fc‐receptors as regulators of immunity

F Nimmerjahn, JV Ravetch - Advances in immunology, 2007 - Elsevier
Receptors for immunoglobulins [Fc‐receptors (FcRs)] are widely expressed throughout the
immune system. By binding to the antibody Fc‐portion, they provide a link between the …

The era of the immunoglobulin A Fc receptor Fcα RI; its function and potential as target in disease

E Aleyd, MH Heineke, M van Egmond - Immunological reviews, 2015 - Wiley Online Library
Immunoglobulin A (IgA) is the most prevalent antibody at mucosal sites, and has an
important role in defense by preventing invasion of pathogens. Traditionally, IgA has been …

Role of secretory IgA in the mucosal sensing of commensal bacteria

A Mathias, B Pais, L Favre, J Benyacoub… - Gut microbes, 2014 - Taylor & Francis
While the gut epithelium represents the largest mucosal tissue, the mechanisms underlying
the interaction between intestinal bacteria and the host epithelium lead to multiple outcomes …

Assessment of monoclonal gammopathies by nephelometric measurement of individual immunoglobulin κ/λ ratios

AR Bradwell, SJ Harding, NJ Fourrier… - Clinical …, 2009 - academic.oup.com
Background: Currently, monoclonal immunoglobulins are identified and quantified from
bands on electrophoretic gels. As an alternative, clonality might be determined by …

Re-thinking the functions of IgA+ plasma cells

JL Gommerman, OL Rojas, JH Fritz - Gut microbes, 2014 - Taylor & Francis
The intestinal mucosa harbors the largest population of antibody (Ab)-secreting plasma cells
(PC) in the human body, producing daily several grams of immunoglobulin A (IgA). IgA has …

Involvement of Fc receptors in disorders of the central nervous system

E Okun, MP Mattson, TV Arumugam - Neuromolecular medicine, 2010 - Springer
Immunoglobulins are proteins with a highly variable antigen-binding domain and a constant
region (Fc domain) that binds to a cell surface receptor (FcR). Activation of FcRs in immune …