Significance: Oxygen is indispensable for aerobic life, but its utilization exposes cells and
tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen …

Globally, about 400 million people reside at terrestrial altitudes above 1500 m, and more
than 100 million lowlanders visit mountainous areas above 2500 m annually. The …

Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and
triggers a bewildering array of both detrimental and beneficial effects in multiple …

Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even
organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon …

Background Intermittent hypoxia applied at rest or in combination with exercise promotes
multiple beneficial adaptations with regard to performance and health in humans. It was …

Preconditioning refers to a procedure by which a single noxious stimulus below the
threshold of damage is applied to the tissue in order to increase resistance to the same or …

The calibrated application of limited-duration, cyclic, moderately intense hypoxia-
reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These …

Purpose Main purposes of pre-acclimatization by hypoxia conditioning (HC) are the
prevention of high-altitude illnesses and maintenance of aerobic exercise performance …

This review explores forms of respiratory and autonomic plasticity, and associated outcome
measures, that are initiated by exposure to intermittent hypoxia. The review focuses primarily …

Rationale: Daily exposure to mild intermittent hypoxia (MIH) may elicit beneficial
cardiovascular outcomes. Objectives: To determine the effect of 15 days of MIH and in-home …