Extracellular vesicles (EVs) are nano-size vesicles secreted naturally by all cells into the
extracellular space and have been recognized as important cell–cell mediators in …

Bone defect and repair is a common but difficult problem in restorative and reconstructive
surgery. Bone tissue defects of different sizes caused by different reasons bring functional …

Background Orthodontic tooth movement (OTM), a process of alveolar bone remodelling, is
induced by mechanical force and regulated by local inflammation. Bone marrow-derived …

Bones serve mechanical and defensive functions, as well as regulating the balance of
calcium ions and housing bone marrow.. The qualities of bones do not remain constant …

Objectives Porphyromonas gingivalis‐LPS regulated bone metabolism by triggering
dysfunction of osteoblasts directly, and affecting activity of osteoclasts through intracellular …

Zinc finger proteins (ZFPs) constitute a crucial group of transcription factors widely present in
various organisms. They act as transcription factors, nucleases, and RNA-binding proteins …

Osteoclast-mediated bone resorption is responsible for bone metabolic diseases, negatively
impacting people's health and life. It has been demonstrated that microRNA influences the …

MicroRNA-206 (miR-206) is a microRNA that is involved in many human diseases, such as
myasthenia gravis, osteoarthritis, depression, cancers, etc. Both inhibition effects and …

Osteoclasts are the cells responsible for the bone resorption process during bone
remodeling. In a healthy situation, this process results from an equilibrium between new …

In the past few decades, nanomedicine research has advanced dramatically. In spite of this,
traditional nanomedicine faces major obstacles, such as blood–brain barriers, low …