Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty

L Ferrucci, E Fabbri - Nature Reviews Cardiology, 2018 - nature.com
Most older individuals develop inflammageing, a condition characterized by elevated levels
of blood inflammatory markers that carries high susceptibility to chronic morbidity, disability …

Examining variation in the measurement of multimorbidity in research: a systematic review of 566 studies

ISS Ho, A Azcoaga-Lorenzo, A Akbari… - The Lancet Public …, 2021 - thelancet.com
Background A systematic understanding of how multimorbidity has been constructed and
measured is unavailable. This review aimed to examine the definition and measurement of …

Is older age associated with COVID-19 mortality in the absence of other risk factors? General population cohort study of 470,034 participants

FK Ho, F Petermann-Rocha, SR Gray, BD Jani… - PloS one, 2020 - journals.plos.org
Introduction Older people have been reported to be at higher risk of COVID-19 mortality.
This study explored the factors mediating this association and whether older age was …

Aging, inflammation and the environment

A Bektas, SH Schurman, R Sen, L Ferrucci - Experimental gerontology, 2018 - Elsevier
The aging process is driven by interrelated mechanisms that lead to the emergence of
characteristic phenotypes that include changes in body composition, energy production and …

Inflammation, frailty and cardiovascular disease

P Soysal, F Arik, L Smith, SE Jackson… - Frailty and cardiovascular …, 2020 - Springer
Chronic inflammation, which is called “inflamm-aging”, is characterized by an increased
level of inflammatory cytokines in response to physiological and environmental stressors …

Inflammation, but not telomere length, predicts successful ageing at extreme old age: a longitudinal study of semi-supercentenarians

Y Arai, CM Martin-Ruiz, M Takayama, Y Abe… - …, 2015 - thelancet.com
To determine the most important drivers of successful ageing at extreme old age, we
combined community-based prospective cohorts: Tokyo Oldest Old Survey on Total Health …

The mediterranean diet slows down the progression of aging and helps to prevent the onset of frailty: A narrative review

C Capurso, F Bellanti, A Lo Buglio, G Vendemiale - Nutrients, 2019 - mdpi.com
The aging population is rapidly increasing all over the world. This results in significant
implications for the planning and provision of health and social care. Aging is physiologically …

Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: A systematic review and meta …

C Custodero, RT Mankowski, SA Lee, Z Chen… - Ageing research …, 2018 - Elsevier
Growing evidence suggests chronic low-grade inflammation (LGI) as a possible mechanism
underlying the aging process. Some biological and pharmaceutical compounds may reduce …

Comparative pathology of aging great apes: bonobos, chimpanzees, gorillas, and orangutans

LJ Lowenstine, R McManamon… - Veterinary …, 2016 - journals.sagepub.com
The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives.
Despite the many similarities, there are significant differences in aging among apes …

Overview of polyamines as nutrients for human healthy long life and effect of increased polyamine intake on DNA methylation

K Soda - Cells, 2022 - mdpi.com
Polyamines, spermidine and spermine, are synthesized in every living cell and are therefore
contained in foods, especially in those that are thought to contribute to health and longevity …